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Psilocybin Produced in Yeast

phys.org

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Re: Psilocybin Produced in Yeast

#101

Post by kaolti »

colechristensen wrote: post #49
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. Dosage is important. There isn't a way to test for potency which would ensure a reliable dose. Argument fallacies: * your anecdotal positive experiences * suggesting superiority because something is "from nature" * referring to "mistakes from the past" without naming any * suggesting superiority that "has been (…

Thanks for listing the technical fallacies in the original comment.

Now let us humans get on with the actual conversation.

Re: Psilocybin Produced in Yeast

#102

Post by andai »

rv-de wrote: post #97
colechristensen wrote: post #96

Earlier quoted context omitted.

>You just did the same, didn't you? No, the side effects are readily available and specific factual data. If you asked ten people to figure out what they were you'd get ten very similar answers. "Mistakes from the past" on the other hand was completely without context that would point anyone to do better than guess what was being referenced.

> There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. You're still owing at least one example for this statement. What side effects do you get from shrooms that you don't get from pure psilocin or one of its prodrugs?

Haven't tried pure psilocybin but I occasionally have gut discomfort which I think comes from the fibers, rather than the psilocybin.

Re: Psilocybin Produced in Yeast

#103

Post by thegabriele »

colechristensen wrote: post #98
samanator wrote: post #67

Earlier quoted context omitted.

Why is that? Do you think they are less sensical than non-users? Or are you implying that the author was under the influence at the time of writing?

There seem to be a specific cluster of personality traits found frequently in hallucinogen users. Whether a selection of who takes the drugs, who talks about it after, or a common effect of the drugs and how they're taken. Someone presently under the influence would probably say something stranger. What seems likely is that they're very potent tools to change how the mind works, possibly for the better if used in the…

Thank you, clearly a more competent way to say what i meant.

Re: Psilocybin Produced in Yeast

#104

Post by colechristensen »

kaolti wrote: post #101
colechristensen wrote: post #49

Earlier quoted context omitted.

There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. Dosage is important. There isn't a way to test for potency which would ensure a reliable dose. Argument fallacies: * your anecdotal positive experiences * suggesting superiority because something is "from nature" * referring to "mistakes from the past" without naming any * suggesting superiority that "has been (…

Thanks for listing the technical fallacies in the original comment. Now let us humans get on with the actual conversation.

Fake thanks are not appreciated, nor are suggestions that it is inhuman to want to have discussions based on sound reasoning instead of irrelevant nonsense. Raise the bar of discussion.

Re: Psilocybin Produced in Yeast

#105

Post by rv-de »

andai wrote: post #102
rv-de wrote: post #97

Earlier quoted context omitted.

> There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. You're still owing at least one example for this statement. What side effects do you get from shrooms that you don't get from pure psilocin or one of its prodrugs?

Haven't tried pure psilocybin but I occasionally have gut discomfort which I think comes from the fibers, rather than the psilocybin.

There are various ways to ingest mushrooms. Having said that - let me assure you, the problem is not just from the fibers it's very well the substance itself. One reason is the activation of serotonin receptors of which there are huge numbers in your gut.

Re: Psilocybin Produced in Yeast

#106

Post by colechristensen »

rv-de wrote: post #97
colechristensen wrote: post #96

Earlier quoted context omitted.

>You just did the same, didn't you? No, the side effects are readily available and specific factual data. If you asked ten people to figure out what they were you'd get ten very similar answers. "Mistakes from the past" on the other hand was completely without context that would point anyone to do better than guess what was being referenced.

> There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. You're still owing at least one example for this statement. What side effects do you get from shrooms that you don't get from pure psilocin or one of its prodrugs?

You'll find nausea and vomiting in just about every discussion about consuming psilocybin mushrooms.

Re: Psilocybin Produced in Yeast

#107

Post by rv-de »

colechristensen wrote: post #106
rv-de wrote: post #97

Earlier quoted context omitted.

> There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. You're still owing at least one example for this statement. What side effects do you get from shrooms that you don't get from pure psilocin or one of its prodrugs?

You'll find nausea and vomiting in just about every discussion about consuming psilocybin mushrooms.

But not just mushrooms - also from psilocin prodrugs like 4-Aco-DMT (also psilocybin is such a prodrug):

https://www.reddit.com/r/researchchemicals/comments/51sbpf/h...

Just google "4 aco dmt nausea" and you'll find more reports than Anne Jones can read in a week.

If you want to learn more about the reasons then serotonin receptors and their distribution in your body would be a place to start your investigation.

Re: Psilocybin Produced in Yeast

#108

Post by ralusek »

andrew_xor_andy wrote: post #39

> the best chemical synthesis methods require expensive and difficult to source starting substrates This type of thing always amazes me about nature -- obviously all the ingredients necessary exist in the soil the mushroom is grown in! Yet the best we can do to mimic nature is get some hard-to-acquire substrates. It's so interesting how, given enough time, the universe can produce a self-replicating organism that can…

> all the ingredients necessary exist in the soil the mushroom is grown in

I can't speak for mushrooms, but for plants, the vast majority of the mass actually comes from carbon in the air (breathes in CO2, takes the carbon, breathes out O2) and obviously water.

Re: Psilocybin Produced in Yeast

#109

Post by throwaway_pdp09 »

svara wrote: post #100
throwaway_pdp09 wrote: post #92

Earlier quoted context omitted.

You: > which is superior to synthetic antidepressants in many cases Then justify this with: > some research has shown the supplement to be as effective as several prescription antidepressants (X > Y) != (X = Y) or in plain English, what you cite does not support your claim. > with a few Google searches You make the claim, you provide the references. > taking your comment as further evidence of an irrational bias agai…

"Effective" in the context of the text I quoted refers to efficacy against depression, but you need to also take the side effects into account when deciding between drugs. Since those vary on a case by case basis and can be significant, there are many cases where St. John's wort is overall the better deal.

You are just dodging and fudging. Let me explain why reality matters.

Those like you who have the blessing of decent mental health and do not understand - seem quite unwilling to understand in many cases - that those such as me who have to deal with this shit for all their lives can be deeply and negatively affected by you lot posting garbage.

If it were a physical disease such as cancer you might be a lot less inclined to do it as you see the immediate link, from lack of proven efficacy to a fatal outcome.

Mental unhealth, though, seems fair game to you. You are insulated from the negative consequences of your idiotic prognostications so you posting crap is like giving a child matches to play with in someone else's house. Not your house, not your house fire, not your problem.

Please grow a little humanity and understanding; it's not a game for us, it can go from our lives made difficult, to our lives irretrievably wrecked.

Re: Psilocybin Produced in Yeast

#110

Post by ralusek »

kfrzcode wrote: post #44

Consciousness studies will be the next frontier and may bring our race further, faster, than space exploration. In my opinion.

I've never once heard a bit of insight from a psychonaut that was particularly game-changing. We're all connected, consciousness is an illusion, societal structures are somewhat arbitrarily defined, etc. These are the existential thoughts of teenagers. Life is just energy, energy is just vibrations, everything is a fractal, etc, these are just the existential speculations of people making baseless claims.

Consciousness as a useful frontier, in my opinion, will only have utility as it intersects with neuroscience and artificial intelligence. Producing consciousness with AI will be game-changing. Altering or affecting consciousness with neuroscience, or allowing consciousness to interact with neuroscience in such a way that interfaces with other technologies will be game-changing, sure.

But giving people psychedelics and having them explore their own consciousnesses is not going to catalyze our society forward by leaps and bounds, that has been done since at least the 60s. I obviously don't care if people do whatever they'd like, I just don't see the point in romanticizing them.

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