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Evolutionary gene loss may explain why only humans are prone to heart attack

sciencedaily.com

101–110 of 130 posts

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#101
post #96
post #93

Earlier quoted context omitted.

I guess he was extrapolating and referring to the idea that carbohydrate consumption is the root cause of most, if not all, modern diseases. An idea held by many, including me.

To say even most modern disease has to do with carb intake ignores all the diseases that clearly aren't even diet related. You could probably get away with saying most diet related diseases are related to carb intake. I'd say that's a stretch, too, though I do suspect, as you do, that the type and quantity of carbs people eat is underappreciated as a factor in many illnesses.

Yes, absolutely. Some diseases are due to pathogens and such. But those should not be "modern", in the sense that said pathogens might not be exactly new. Maybe you could say anthropogenic diseases such as lung cancer from smoking or esophagus cancer from drinking are modern, though.

What I meant by "modern diseases" in my comment is a group of non-communicable diseases or so-called "diseases of civilization".

"Diet-related" is rather ambiguous, so different lines might be drawn there. As an example, would you say Alzheimer's is a diet-related disease? What about melanoma and/or sunburn?

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#102
post #54

Earlier quoted context omitted.

I'm not sure that I wish CMAH gene back: > Interestingly, the evolutionary loss of the CMAH gene appears to have produced other significant changes in human physiology, including reduced human fertility and enhanced ability to run long distances. Reduced fertility doesn't seem for me important, we have a contraception for that. But enhanced ability to run long distances seems very convenient. I can ride a bicycle or…

I read somewhere that running very long distances is basically the only physical thing humans can do better than any other animal.

Same, i heard it was so we could just run down prey we had injured.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#103
post #96

Earlier quoted context omitted.

To say even most modern disease has to do with carb intake ignores all the diseases that clearly aren't even diet related. You could probably get away with saying most diet related diseases are related to carb intake. I'd say that's a stretch, too, though I do suspect, as you do, that the type and quantity of carbs people eat is underappreciated as a factor in many illnesses.

Yes, absolutely. Some diseases are due to pathogens and such. But those should not be "modern", in the sense that said pathogens might not be exactly new. Maybe you could say anthropogenic diseases such as lung cancer from smoking or esophagus cancer from drinking are modern, though. What I meant by "modern diseases" in my comment is a group of non-communicable diseases or so-called "diseases of civilization". "Diet-…

Ah I either missed or misunderstood the use of "modern" there. I can't speak to the relationship between diet and melanoma or Alzheimer's, but I understand your point.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#104
post #86

Earlier quoted context omitted.

Rabbits, too. The whole premise behind this headline seems bogus.

The headline seems bogus but the article says that "naturally occurring coronary heart attacks due to atherosclerosis are virtually non-existent in other mammals." Atherosclerosis is the cause of only "one-third of deaths worldwide due to cardiovascular disease" so other causes could still apply to other mammals. For example, "chimp heart attacks were due to an as-yet unexplained scarring of the heart muscle." Of cou…

Elephants that live in savannas in Africa are prone to atherosclerosis, while those living in forest areas are not. [1] discusses that it can be due to food. In savanna elephants are forced to feed on grains and dry grass, while in forest they feed on leaves, which is probably more natural.

[1] Staffan Lindeberg. Food and Western Disease: Health and Nutrition from an Evolutionary Perspective

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#105
post #75

Interesting, I was always under the impression that chipmunks were susceptible to heart attacks. I can't remember where I read it and I can't find a current source but you are apparently not supposed to harass chipmunks because they can experience stress induced heart attacks when threatened/chased. I've also seen potential evidence for this when my cat chased one around a parking lot only for it to collapse after sp…

Rabbits, too. The whole premise behind this headline seems bogus.

The important animals are other apes and primates, when considering the evolution of disease. If none of them have it but humans do, then it likely came about recently. This means that it has independently evolved in humans and other animals (like rodents) that may have it. Makes for a misleading headline, though.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#106
post #37

Earlier quoted context omitted.

Cats, being obligate carnivores and lacking a proper mechanism for extracting energy out of fatty acids (e.g. ketogenesis in humans), have actually very efficient kidneys to dispose of all the nitrogen coming from their protein-exclusive metabolism. Domestic cats are at risk, but that is more a result of domestication and improper feeding (carbohydrate) than evolution or genetics. Unless I am missing something, of co…

Whenever I see comments blaming carbohydrate intake for large swaths of problems I find it challenging because I agree and then feel that I am seen as a heretic or extremely gullible. Do you ever feel that way?

“carbohydrate“ is extremely bad term in nutrition. There is fundamental difference between eating whole food plants like potatoes or drinking sugary drinks. Yet both are formally carbohydrates.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#107
post #93
post #89

Earlier quoted context omitted.

I doubt anyone would think you a heretic for believing that about pure carnivores like cats.

I guess he was extrapolating and referring to the idea that carbohydrate consumption is the root cause of most, if not all, modern diseases. An idea held by many, including me.

In Mongolia in rural areas people eat just meat. Dearth from heart decease and liver cancers are leading causes of dearth there. On the other hand, life expectancy in Mongolia is 70 years, while in mostly vegetarian India it is 69.5. Just from that one can easily see that blaming one particular food group is not productive.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#108
post #75

Interesting, I was always under the impression that chipmunks were susceptible to heart attacks. I can't remember where I read it and I can't find a current source but you are apparently not supposed to harass chipmunks because they can experience stress induced heart attacks when threatened/chased. I've also seen potential evidence for this when my cat chased one around a parking lot only for it to collapse after sp…

Apparently, after their hibernation, bears can have heart attacks too https://youtu.be/wT6GeJ9TsUw?t=52

But that would be from malnutrition, not atherosclerosis.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#109
post #43
post #21

Earlier quoted context omitted.

I mean, this was when amputation and leeches was the pinnacle of medicinal triage. Life expectancy hit 49 in 1900 - for most of the 1800s it was below 40, a fact that still blows my mind today.

...are you aware that most of that low life expectancy was caused by infant and child mortality? Once you lived past 15, you were expected to stick around at least to your 60s, if not more. So yes, modern medicine is a Herculean effort in many ways. One of them is that it saves so many of our otherwise very frail and helpless children.

Thanks for this - I was using life expectancy at birth. Looks like it was around 55->60 from 1850->1900 if you lived to 5 looking at this chart: https://ourworldindata.org/uploads/2013/05/Life-expectancy-b...

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#110

I have the feeling this has much more to do with our self inflicted lifestyle than genetic factors. Maybe no other animal is just that stupid.

> Maybe no other animal is just that stupid. Have you ever owned a cat or dog? My experience is that a percentage of them will overeat unless constantly monitored, eat things that are outright dangerous, etc. What is it that makes humans the stupid ones, here?

Labradors usually have a genetic disorder that causes them to gorge themselves, so they are highly prone to obesity. They are also very popular breeds in the US.

https://en.wikipedia.org/wiki/Labrador_Retriever#Inherited_d...

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