Shit, what does this mean for children and their development? Ibuprofen has been our go-to analgesic since our kids were born.
Ibuprofen alters human testicular physiology
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Re: Ibuprofen alters human testicular physiology
#102Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
Asprin seems to increase intestinal permeability.
Re: Ibuprofen alters human testicular physiology
#103If you hang around bodybuilding forums you will hear to avoid Ibuprofens as they hurt your ‘gains’ Perhaps bro-science was right in this case
Bodybuilders tend to not rely on their testes for testosterone production though
Re: Ibuprofen alters human testicular physiology
#104Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
As long as dengue fever (that has exactly the same initial symptoms as a flu) is not a possibility...
Re: Ibuprofen alters human testicular physiology
#105Earlier quoted context omitted.
1000 cases in the US, which means you're about 30x more likely to die in a car accident in any given year. Also, the syndrome isn't immediately lethal. When people worry about infinitesimally small risks, it always makes me chuckle.
That's 1000 cases when we restrict children from taking aspirin, it could be a lot more once we let them
No, it was under 1000 cases per year in the US before the association with aspirin was known. Over the next 14 years it dropped to about 2 per year.
Re: Ibuprofen alters human testicular physiology
#106I'm suffering from Ankylosing Spondilytis (a non-cureable chronic disease similar to Artritis). Let me tell you, the side effects are the least of my concerns when I'm in chronic pain.
Re: Ibuprofen alters human testicular physiology
#107Earlier quoted context omitted.
> 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg. Most people take 1-2 capsules (400mg), and the dosage documentation says no more than 8 per day (1600mg). The study seems to demonstrate people using the drug well within its over-the-counter maximum dosage. (When I tore up my knee as a teenager, my doctor prescribed it at about double that rate.)
If your doctor gives an Rx, they acknowledge that they're making a tradeoff and that it's the most applicable one for your overall health. I'm sure studies like this are helpful information for making such decisions, but this definitely doesn't seem to mean "taking ibuprofen will make you infertile". For what it's worth, I've also been Rx'd large ibuprofen dosages for a period of weeks at various times, and I've had…
I think I understand what you're saying, but anecdotal evidence isn't really the point here. The article is pointing toward a societal trend, not one that is likely to be observed on a case by case basis.
That said I do agree. All medications are a trade off of some sort. Usually the consequences aren't as bad as the effects of the drug, and I think this is no exception.
Re: Ibuprofen alters human testicular physiology
#108Earlier quoted context omitted.
I tend to use naproxen but something tells me that would kill me as well
Funny thing, naproxen is much kinder to your stomach than ibuprofen, but it's not generally used (and may be prescription-only?), in Australia at least. It does, however, carry a minutely increased risk of heart attack / stroke. I guess they'd rather give 1000 people ulcers than 1 more person die in a lawsuit-attracting fashion.
Naproxen is OTC in the US, as Aleve, but you need a prescription for higher doses, like with ibuprofen.
Re: Ibuprofen alters human testicular physiology
#109At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.
Is the /d per day? If so that's well within what I've seen "normal" people take. A regular Advil is 200mg. The usual dose is two pills, so 400mg. If your larger it's common to take three or four pills. Multiply by a dose ever six hours and it's quite easy to get to 3200mg per day.
Yup; after seeing my mom be recommended 3-4 pills every 6 hours as needed for knee pain, I sure don't bother with just 2 pills as a 200# male if I "need" ibuprofen. I either take 3, or I take nothing.
Fortunately I have no chronic issues, rarely need ibuprofen (in fact I'm paranoid about taking it for muscle aches as I've always felt it must harm muscle development, which seems to be catching traction as a theory), and generally avoid medications altogether, but it seems like if you're taking it, might as well take a dose that will do something.
Re: Ibuprofen alters human testicular physiology
#110everything i read here refers to effects on testosterone levels. how does this relate to actual fertility (that can be measured in a semen analysis)? would lower testosterone levels affect count, motility, morphology, etc?