11–20 of 28 posts
I find this much less interested in getting clicks, and easier to read: http://en.wikipedia.org/wiki/Sirolimus
"Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population"
No. There is a greater fool at the end of many paths of research and development, the wallet or collection of wallets that indirectly bankrolls the work. Early for-profit investment occurs because investors believe they can sell their stake at a higher price down the line. Other reasons exist, such as the desire to do good in the world, but are entirely secondary. Most investors, and certainly the wealthier ones, hav…
Slowing the damaging processes of aging should probably be part of a proper anti-aging strategy IMO, as it's easier to fix things that are slightly broken in comparison to things which are radically broken. I agree that mTOR based technologies are probably a dead end (no pun intended) in terms of anti-aging research, but it's such a fundamental pathway that we'd be stupid not to investigate it more fully and learn as much as possible as we can.
That said, your objections to this line of scientific inquiry are spot on. Dreaming bigger isn't what gets Novartis paid, though. Incremental plays are the best they can work for, I think. Leave it to biotech startups or other do-big-or-die research groups (if any exist) to try tackling the harder problems.
I find this much less interested in getting clicks, and easier to read: http://en.wikipedia.org/wiki/Sirolimus
It's also a lot better at telling us the downsides. "Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population"
The previous line actually sheds more light on this: "As with all immunosuppressive medications, in theory, sirolimus may decrease the body's inherent anticancer activity and allow some cancers that would have been naturally destroyed to proliferate."
I find this much less interested in getting clicks, and easier to read: http://en.wikipedia.org/wiki/Sirolimus
It's also a lot better at telling us the downsides. "Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population"
It's likely that aging is a product of multiple such trade-offs. I very, very strongly doubt that SENS will be achieved by simply adjusting one or two knobs.
One possibility is that we just get really, really, REALLY good at detecting and zapping cancer, and then we turn off all the senescence-generating anti-cancer safety switches and decay mechanisms and just play whack a mole with the cancers when they arise. So you get to live two or three times as long but you're in for cancer removal at least once per decade.
This sticky scroll nonsense works for landing pages, not for articles that people are supposed to read.
"A Canadian medical expedition had collected the soil from beneath one of the mysterious stone heads on Easter Island, a speck in the middle of the Pacific Ocean."
.. combined with this story:
http://www.disclose.tv/news/Study_Ancient_Humans_Bred_with_C...
.. I'm starting to think that Szukalski wasn't such a crackpot after all.
(http://en.wikipedia.org/wiki/Stanis%C5%82aw_Szukalski)
Are we perhaps on the brink of a new era of Zermatism? Yikes, what a scary thought... ;)
Earlier quoted context omitted.
I do like the progress bar at the top, at least it was informative as I really could not tell how much more article I had to read was left.
And it helps you figure out when exactly you hit the completely unrelated article about shopping malls or something at the end.
Wow! This: "A Canadian medical expedition had collected the soil from beneath one of the mysterious stone heads on Easter Island, a speck in the middle of the Pacific Ocean." .. combined with this story: http://www.disclose.tv/news/Study_Ancient_Humans_Bred_with_C... .. I'm starting to think that Szukalski wasn't such a crackpot after all. ( http://en.wikipedia.org/wiki/Stanis%C5%82aw_Szukalski ) Are we perhaps on th…
Earlier quoted context omitted.
It's also a lot better at telling us the downsides. "Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population"
There is a school of thought in anti-aging research that some of the mechanisms of aging, such as telomeres, are adaptations to prevent cancer. So evolutionarily there might have been a life span / cancer risk trade-off. This of course would have been optimized to maximize long-term reproductive success, providing a long enough life span to have, raise, nourish, and educate children while minimizing the risk of dying…