I've always wondered at what distance it would be impossible for current technology to detect life on earth.
For direct detection of life, that's still an open question. I remember a poster done by a grad student who looked at whether life would be detectable from the Moon, looking at the Earth. This was tested with data from one of the outer solar system probes which did a lunar flyby on its way out (Cassini?). The result, IIRC, was inconclusive -- you could see signs of life, but not anything that was absolutely definitive proof.
Indirect evidence might be provided by spectra of the atmosphere observed via solar transit. A biome is likely to have different spectra than would be predicted by inorganic atmospheric physics. Still, that's making some assumptions about what extraterrestrial life would be like, and only only visible along the elliptic plane.