Look around for the kind of company you want to work for. Explore outfits mentioned on HN, but also on sites like TechCrunch.
When you find a few, explore their tech stacks and see if any interest you. You don't need to be an expert in the technology, but you need to like it.
Can you visualize a kind of dream role there? It's great that you're ok to start over (I love starting over, like re-learning French or re-reading my ancient copy of K&R).
Look for best practice in CV's - google them and see what makes sense and what doesn't. Revise your CV so it's better. Apply lots, fail lots, take the agile approach to job hunting. Don't get disheartened when you don't get the one you really want, you WILL get there!
Cheers, Andrew.