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For Safer Food, Just Add Viruses

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Re: For Safer Food, Just Add Viruses

#11

Post by bhickey »

Amadou wrote: post #7
Ravengenocide wrote: post #5

Earlier quoted context omitted.

According to this link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278644/ phages target specific pathogenic bacteria, and "[...]phages only minimally impact non-target bacteria or body tissues". So that would mean that even though they target bacteria, they would only target a specific bacteria and not all.

You do have to wonder if they aren't over-stating the specificity. The older I get, the more I come to expect the unstated "but..." on claims like that. As the saying goes, "When it's too good to be true, it probably is."

I don't think they're overstating this claim. It's a double-edged sword.

If you have an infection your doctor can give you antibiotics and send you home. Antibiotics tend to be wide spectrum and kill entire classes of bacteria, like gram-positive, indiscriminately.

A phage that kills one strain of E.coli might be completely incapable of infecting a closely related E.coli strain. Thinking that a single phage could be effective against closely relate pathogens, for example E.coli AND Salmonella, is wishful thinking. This might have the upside of preserving gut flora, but it's easy to see how it would confound treatment: some things are very difficult to grow in vitro.

Re: For Safer Food, Just Add Viruses

#12

Post by alecco »

manmal wrote: post #3

Given that the human digestive tract (reportedly) contains more bacteria than the human body has cells, and they are vital to our survival, how can spraying bacteria-killers on food not be harmful?

I've read phages are very specialized and tied to their target type of cell.

Re: For Safer Food, Just Add Viruses

#13

Post by klipt »

manmal wrote: post #3

Given that the human digestive tract (reportedly) contains more bacteria than the human body has cells, and they are vital to our survival, how can spraying bacteria-killers on food not be harmful?

Wouldn't cooking destroy the phages?

Re: For Safer Food, Just Add Viruses

#14

Post by skore »

lifeformed wrote: post #9

Viruses seem so weird to me. They're naturally emergent nanobots.

> naturally emergent nanobots

That's an astonishing thought. "Look at all those bacteria that we cannot possibly eliminate with conventional means!" - "Well, maybe in the future, we could build nanobots that kill them individually...".

Yep, already there. Viruses. Really seems like a terrific shortcut.

Re: For Safer Food, Just Add Viruses

#15

Post by derefr »

lifeformed wrote: post #9

Viruses seem so weird to me. They're naturally emergent nanobots.

I wouldn't really call them nanobots; they don't function in any active manner. They're really just like their digital counterparts--malicious program data that gets executed by our cellular machinery.

Re: For Safer Food, Just Add Viruses

#16

Post by Peaker »

derefr wrote: post #15
lifeformed wrote: post #9

Viruses seem so weird to me. They're naturally emergent nanobots.

I wouldn't really call them nanobots; they don't function in any active manner. They're really just like their digital counterparts--malicious program data that gets executed by our cellular machinery.

They are not pure code. They come with a protein coat and a bunch of proteins/enzymes to bring the code to the cell or nucleus, and sometimes more functions.

Re: For Safer Food, Just Add Viruses

#17

Post by derefr »

Peaker wrote: post #16
derefr wrote: post #15

Earlier quoted context omitted.

I wouldn't really call them nanobots; they don't function in any active manner. They're really just like their digital counterparts--malicious program data that gets executed by our cellular machinery.

They are not pure code. They come with a protein coat and a bunch of proteins/enzymes to bring the code to the cell or nucleus, and sometimes more functions.

Sure, but those are produced by the cell at the behest of the viral code; not produced by the virus. The freshly-minted copy of the virus doesn't get to react to stimuli by producing proteins once it has left its host cell. It's a lot more like the relationship between, say, pollen spores and the gametophytes they contain.

To put it another way--a post-code and stamp on an envelope will get the postal system to deliver its contents to the right destination. That doesn't mean the contents are functioning to deliver themselves there; they're relying on a working mail-transport system that wants to take them there.

Re: For Safer Food, Just Add Viruses

#18

Post by skj »

klipt wrote: post #13
manmal wrote: post #3

Given that the human digestive tract (reportedly) contains more bacteria than the human body has cells, and they are vital to our survival, how can spraying bacteria-killers on food not be harmful?

Wouldn't cooking destroy the phages?

The phages are applied after cooking, but before packaging.

Re: For Safer Food, Just Add Viruses

#19

Post by manmal »

aroch wrote: post #6
Ravengenocide wrote: post #5

Earlier quoted context omitted.

According to this link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278644/ phages target specific pathogenic bacteria, and "[...]phages only minimally impact non-target bacteria or body tissues". So that would mean that even though they target bacteria, they would only target a specific bacteria and not all.

Phages will and do target E. Coli and other "pathogenic" bacterium that do in fact reside in your digestive system

Exactly my concern. There are special (very expensive) bacterial supplements (e.g. Mutaflor) which reportedly help people with Colitis Ulcerosa and other inflammatory disease, and they are nothing other than special E. Coli strains. I wouldn't want a supplier to silently introduce something that can kill beneficial gut flora. This is the kind of stuff that lifestyle diseases are made of.
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