A lot of startups adopt a layout similar to that presented in the article for their website, which makes it easier to know quickly what's going on. Is it bad from a differentiation/branding point of view? Maybe, I don't know. I don't think I'm very sensitive to this, but this might be a very important point.
Take worrydream.com for instance. I checked it out yesterday, and the content of the website is absolutely fantastic (I'm a new fan of Bret Victor). But the website's design is very, very original, and it took me some time to get used to it. This is not to say that it's not good. It's different. And different requires efforts (well worth it in this case).