Currently doing web and backend stuff with it. Works very well. Also put my money in there as a consortium member. Really a great feel and awesome community.
Neat! What sort of web stuff? Using Seaside or something else? Do you think you could send me an email (in my profile here), I'd love to pick your brains about using Pharo in production!
So, load balancing and monitoring you can do with things like nginx and monit.
Of course, I am no in the league of doing the next Twitter. It may keep up tough.
I am tying everything together with RabbitMQ, so scaling is doable.
Storage for blobs etc is in Riak.