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Nicotine as a useful stimulant

gwern.net

11–20 of 138 posts

Re: Nicotine as a useful stimulant

#11
20+ years smoker, about 30 cigarettes a day mostly hand-rolled. I quit 6 months ago and despite vaping turned into a kind of zombie until I discovered snus.

Then I understood what I had missed all this time: I love nicotine, and the surprising thing is that without all the toxic stuff in cigarettes it's not as addictive as it's made out to be.

I often go hours without a portion of snus and completely forget about it, while I could not stay away from cigarettes for more than a couple of hours without getting restless.

Re: Nicotine as a useful stimulant

#12

I vaped for a while on the strength of this analysis, but eventually concluded that stimulants weren't worth the blood pressure increase. I still vape zero nicotine ejuice though. That stuff is delicious.

Your body will rapidly develop tolerance for the blood pressure increase caused by many stimulants (caffeine, nicotine). You will likely see no more effect after just a few days.

What do you mean by no more effect? No more blood pressure increase? Or no more cognitive stimulant effect?

Re: Nicotine as a useful stimulant

#13

Earlier quoted context omitted.

Your body will rapidly develop tolerance for the blood pressure increase caused by many stimulants (caffeine, nicotine). You will likely see no more effect after just a few days.

What do you mean by no more effect? No more blood pressure increase? Or no more cognitive stimulant effect?

No more blood pressure increase. You can probably also develop tolerance for the other effects of your chosen stimulant, but maybe not as rapidly.

Re: Nicotine as a useful stimulant

#14
post #6

I'm very sad this article doesn't mention the most interesting quality of nicotine: depending on how it is administered, it will act either as a sedative, or a stimulant! There's not (m)any other molecules out there that do this, so it's quite a novel research target!

Which ROA causes it to act as a sedative? That's very curious, indeed!

Re: Nicotine as a useful stimulant

#15
post #7

I vaped for a while on the strength of this analysis, but eventually concluded that stimulants weren't worth the blood pressure increase. I still vape zero nicotine ejuice though. That stuff is delicious.

i'm vaping and lowering my doses of nicotine while i go. hopefully, i can get to zero nicotine.

I did the same, then switched to snus and stopped vaping. I thought the important thing was having something my hand, and some smoke to blow, then I understood that I only care about nicotine. :)

Re: Nicotine as a useful stimulant

#16

I can't imagine life without stimulants. I hope to move off into the woods one day and live a completely natural lifestyle for a while. Reset myself. No caffeine, no nicotine, no amphetamines. Just me, a dog, and a nice ranch property in the middle of nowhere. Meanwhile, nicotine is a staple of my day-to-day. I quit smoking a long time ago, now I stick to Swedish snus and vaping. For a period I was chewing gum too. D…

Snus is an awesome alternative to smoking. I've tried chew and nicotine lozenges, but snus is a happy medium. I've come up with a way to get off nicotine, which I do from time to time: dissolve about 8 nicotine lozenges in a bottle of water. Take a sip when craving hits. The craving goes away immediately. ymmv.

Re: Nicotine as a useful stimulant

#17

I can't imagine life without stimulants. I hope to move off into the woods one day and live a completely natural lifestyle for a while. Reset myself. No caffeine, no nicotine, no amphetamines. Just me, a dog, and a nice ranch property in the middle of nowhere. Meanwhile, nicotine is a staple of my day-to-day. I quit smoking a long time ago, now I stick to Swedish snus and vaping. For a period I was chewing gum too. D…

Snus is an awesome alternative to smoking. I've tried chew and nicotine lozenges, but snus is a happy medium. I've come up with a way to get off nicotine, which I do from time to time: dissolve about 8 nicotine lozenges in a bottle of water. Take a sip when craving hits. The craving goes away immediately. ymmv.

So, you get off nicotine by going on nicotine?

Re: Nicotine as a useful stimulant

#18
"Effects of nicotine on perceptual speed" [1] is behind a paywall, and I can't tell from the abstract whether the results also apply to non-smokers.

However, the abstract of another of the articles, "Effects of Cigarette Smoking on Performance in a Simulated Driving Task" [2] states that the effect was only measured on minimally abstinent smokers.

Are any of the other studies measuring the beneficial effects of nicotine on non-users (and non-users only)?

My anecdotal experience when I quit (the first 2 times, couple of months each) as well as the first time I smoked was that the first couple of cigarettes had absolutely no effects, whatsoever.

So the last time I quit (about 2 years ago), I just kept at it. After about 3 months any previously observable decline in performance and ability to focus was gone. Most of it was gone in the first 3 weeks actually, with only slight remains of increased irritability persisting for 2 more months.

That makes me suspect that nicotine only has a beneficial effects on nicotine users (instead, lack of nicotine is what causes the opposite of the measured effect for users).

But even if such benefits exist, I feel that the they aren't worth it. The inability to function without nicotine, the constant drive to get more - it feels like slavery, and I'll never go back to that.

And I cringe when I read things like:

    There is addiction but it’s drastically overestimated by     
    almost everyone and may been conflated with the habit-formation 
    capability
Because in my experience its completely, totally wrong. I could clearly separate 2 phases that I went through when I quit:

1. the nicotine desire phase - First 48 hours. Incredibly, painfully hard. Strong desire to place a sticker on me or just light a cigarette and make it all go away. This is what kept me a user for 7 years and helped me come up with various excuses just to continue.

2. The learning-to-live phase: A hard but somewhat joyful period where I would recognize the habitual desire to light up a cigarette associated with various activities.

The second phase had 3 different stages for every smoking habit I have developed. For example, at first I couldn't imagine drinking coffee without a cigarette.

Then after the first time it felt like I'm getting no joy from the coffee. The second time it felt okay, but slightly incomplete. Finally, the third time it was all good.

The awesome part was realizing that I just learned how to drink coffee without cigarettes. And it was super-easy: just do it 3 times. Joy! Repeat with all other problematic activities.

This happened with all activities that I associated with smoking. Removing the habits felt easy. Getting off the nicotine felt almost impossible. Luckily, the necessary time for the second one was much shorter (I still had tiny activity-induced cravings couple of months after I quit)

[1]: http://cercor.oxfordjournals.org/content/19/9/1990.abstract

[2]: http://www.karger.com/Article/Abstract/119229

Re: Nicotine as a useful stimulant

#20
post #9
post #4

Once demonization has eradicated tobacco from the public's grasp, these benefits may be sold back in pill form for an even greater margin of profit. Yay Capitalism!

You should read the article. He prices out nicotene for you. It's... not going to make anyone wildly rich the way cigarettes did.

Unless 'someone' gets smart to the system and starts adding tax to the quit smoking products, of course.

I think we're seeing some of this now, with the greater attention being paid to e-cig products.

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