I use the standard Dvorak layout. It hasn't been that big a deal for me.
Things have gone something like this:
1) Learn Dvorak at a time when I only used my own machines. Stay that way for ~3 years.
During this time, after my typing speed and error rate had reached QWERTY levels, the occasional use of QWERTY on someone else's PC was highly annoying.
2) Spend 2-3 years in jobs involving near-daily use of machines I couldn't switch off QWERTY, but still did most of my work on Dvorak.
A few weeks into this, I was able to use QWERTY effectively again, still typing faster than most people ever can (though slower and more error-prone than I was with Dvorak).
3) Go back to exclusively using my own machines for ~2 years.
After a while, annoying to use QWERTY, but not nearly as bad as during period #1.
4) Spend ~9 months in similar situation as #2 again.
After a while, same as 2, a few weeks in things were pretty OK.
5) Now (for ~2 years), using only my own machines.
Occasional QWERTY is annoying, but even better than during #3.
I only speak English, but I suspect switching between Dvorak and QWERTY is kind of similar to switching between a language you use a lot and one you use a little. Degree of fluency in the little-used language goes up and down based on how much practice you're getting.