My only issue with blueprint and compass was that it seems overly complicated for what I'm trying to do so far. I'm not a CSS guru so maybe I'm missing the point but is there a good reason to use a CSS framework on medium sized projects? Or, rather, is there something inherently nice about using grids for translating design to markup? It just seems like the framework adds a lot of code and styles that you're never go…
No, not really.
> is there something inherently nice about using grids for translating design to markup?
Only if you want your markup tightly coupled with page layout.