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Melatonin impairs morning cognition in healthy young adults (2023)

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Re: Melatonin impairs morning cognition in healthy young adults (2023)

#11

Post by turtleyacht »

mutagen wrote: post #4

This thesis appears to be related or the underlying research: https://d.lib.msu.edu/etd/51312 Indicates 2mg and 5mg were given along with the placebo. While these are common dosages available in the US, these are higher dosages than recommended by at least some sleep experts. The thesis doesn't seem to differentiate between the dosages when evaluating cognitive processes. Now I want to evaluate my sleep stack against…

Coffee isn't mentioned. Morning cognition could be impacted by whether subjects take caffeine before starting tasks.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#12

Post by ororroro »

gwern wrote: post #3

Hard to discuss this with only a short abstract. They don't even give a dose or formulation of the melatonin, and details like "We found no significant differences between the melatonin and sleep groups on any of our sleep measures." raise more questions than they answer.

The study is on "healthy young adults". How much improvement would you expect on someone who is already "healthy"? It's not like they are going to ascend and become superhuman.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#13

Post by WarOnPrivacy »

Not sleeping impairs my morning cognition - a lot. Melatonin is part of the rotating stacks I use to mitigate insomnia.

My mornings have always been impaired, going back to pre-school. Meds don't make my mornings any worse than my baseline.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#14

Post by ajkjk »

My understanding is that you ought to take melatonin in small doses (0.3 or so) an hour or two before sleep in order to get tired, whereupon you sleep (normally, ish, unless you take too much and then you get crazy dreams or sleep paralysis). If I take it and go right to bed I always wake up still in the 'window' of its effect.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#15

Post by dripdry45 »

colordrops wrote: post #8
gwern wrote: post #3

Hard to discuss this with only a short abstract. They don't even give a dose or formulation of the melatonin, and details like "We found no significant differences between the melatonin and sleep groups on any of our sleep measures." raise more questions than they answer.

Anecdote - I've used it dozens of times and I'm always foggy in the AM, so I avoid it if I have to be sharp the next morning. Perhaps it's a coincidence and this study is flawed, but I can believe it pretty easily.

same here. I use 5HTP instead, apparently the same chemical pathway just goes in at a different point. no fog in the morning at all. Nice and sharp, feel good.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#17

Post by johntash »

WarOnPrivacy wrote: post #13

Not sleeping impairs my morning cognition - a lot. Melatonin is part of the rotating stacks I use to mitigate insomnia. My mornings have always been impaired, going back to pre-school. Meds don't make my mornings any worse than my baseline.

What else is part of your rotating stacks? Asking as someone who melatonin doesn't seem to help much

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#18

Post by mutagen »

wincy wrote: post #9
mutagen wrote: post #4

This thesis appears to be related or the underlying research: https://d.lib.msu.edu/etd/51312 Indicates 2mg and 5mg were given along with the placebo. While these are common dosages available in the US, these are higher dosages than recommended by at least some sleep experts. The thesis doesn't seem to differentiate between the dosages when evaluating cognitive processes. Now I want to evaluate my sleep stack against…

I take 300mcg when I’m having a hard time getting to sleep or if I’ve had a lot of caffeine. Mostly because Scott Alexander told me to.

Yeah I'm in the 300 mcg camp, I take a time release formulation, try to take it early but often it isn't far off bedtime.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#19

Post by dripdry45 »

redrove wrote: post #10

Could it just be dosage? Commonly found dosage is 10-20x what you'd actually secrete and IIRC absorption is actually quite good.

My understanding is that melatonin can overload certain receptors and cause an issue with fogginess since it works directly on the brain. 5HTP is more broad and is “gated“ on the same metabolic pathway, so cannot overload the system the way melatonin does.

Re: Melatonin impairs morning cognition in healthy young adults (2023)

#20

Post by mutagen »

johntash wrote: post #17
WarOnPrivacy wrote: post #13

Not sleeping impairs my morning cognition - a lot. Melatonin is part of the rotating stacks I use to mitigate insomnia. My mornings have always been impaired, going back to pre-school. Meds don't make my mornings any worse than my baseline.

What else is part of your rotating stacks? Asking as someone who melatonin doesn't seem to help much

Not OP but I seem to get a benefit from GABA. Valerian root is effective at inducing sleep but leaves me groggy and I've had paradoxical anxiety reactions to it and there's some question around its longer term use. L-theanine is often mentioned but I'm not sure I benefit. Magnesium glycinate is another that comes up often.
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