The psilocybin dosage in this study seems to be miniscule (5mg, 25mg), which is fair given its controversial reputation (undeserved IMO) and researchers’ plausible risk aversion. However, to see meaningful improvements in TRD I’d expect larger doses to be necessary for most people.
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
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Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#12Earlier quoted context omitted.
It may simply be that the intense disruption of a 5 hour long experience of chemically-induced novel pleasures - in people who'd long forgotten any form of enjoyment at all - while also being under special attention from caring professionals, is Very Nice Indeed. And that very nice experiences are the most direct salve that exists, when it comes to ameliorating a lifetime of unpleasant ones. "I can say wth certainty…
There’s more evidence it is than it’s not. And, yes, even people who have been super stubbornly against psychedelics only very seldom come to regret taking some. Which you cannot say for other recreational or sedating stuff at all. According to the GPTs, the LSD ranks the bottom in the chart of ‘damage done to your organism’ while alcohol tops it every time.
At the same time, using LSD once is higher risk than one night of drinking.
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#13I've always wondered if one dose of LSD could have been responsible for a fundamental change in my mind. There were other things of course going on in those college years, but I can say wth certainty that I became a very different person at some point in those early to mid twenties. It's such that I have wondered if those I know who suffer various emotional issues might not benefit from a hallucinogenic trip—perhaps…
If you have a messy room, you don't throw a grenade in hopes that after explosion things will end up in "better" places than before.
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#14Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#15The psilocybin dosage in this study seems to be miniscule (5mg, 25mg), which is fair given its controversial reputation (undeserved IMO) and researchers’ plausible risk aversion. However, to see meaningful improvements in TRD I’d expect larger doses to be necessary for most people.
I'm of the same opinion. Also apparently one recipient ended up with HPPD from this medical study, when they essentially only had 30mg of psilocybin every 6 weeks? I think prior history should be checked there.
> Two serious adverse reactions were reported after psilocybin, 25 mg, including 1 case of hallucinogen persisting perception disorder.
The psychotherapeutic therapy probably did the heavy lifting for any positive effects. At least from what I can tell, for depression, the magic of psychedelics is the reckoning you're faced with to clean up your act and think of more than just yourself.
Still, always glad to see more studies on psilocybin!
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#16Earlier quoted context omitted.
There’s more evidence it is than it’s not. And, yes, even people who have been super stubbornly against psychedelics only very seldom come to regret taking some. Which you cannot say for other recreational or sedating stuff at all. According to the GPTs, the LSD ranks the bottom in the chart of ‘damage done to your organism’ while alcohol tops it every time.
At the same time, using LSD once is higher risk than one night of drinking.
This is absolute nonsense and is not backed by any sane scientific evidence. Using alcohol even once, in the quantities readily made available everywhere where alcohol is available, can finish you off in the most diverse and bizarre ways.
What’s even more ridiculous is the fact even quarter pill of the Xanax kind mixed a very limited amount of alcohol gets you potentially higher than most psychedelics when properly dosed. And both opioids are super well available…
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#17Earlier quoted context omitted.
There’s more evidence it is than it’s not. And, yes, even people who have been super stubbornly against psychedelics only very seldom come to regret taking some. Which you cannot say for other recreational or sedating stuff at all. According to the GPTs, the LSD ranks the bottom in the chart of ‘damage done to your organism’ while alcohol tops it every time.
While using GPTs to explore my own bias, I liked the re-phrasing "the chemical opens a window so that the profoundly human experience of care, safety, and novel emotion can finally get through to a brain that had walled itself off". Highlighting how the human experience is an intrinsic part of the benefit seen, but not the only part. (and I totally agree with you, alcohol is one of the strongest and also one of the l…
Indeed I suppose many are on the same opinion here… save for some super stubborn uneducated jerks who keep downvoting all my ‘Alcochol-is-likely-worse-than-LSD’ comments without even getting into reasonable argument.
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#18Earlier quoted context omitted.
At the same time, using LSD once is higher risk than one night of drinking.
This is absolute nonsense and is not backed by any sane scientific evidence. Using alcohol even once, in the quantities readily made available everywhere where alcohol is available, can finish you off in the most diverse and bizarre ways. What’s even more ridiculous is the fact even quarter pill of the Xanax kind mixed a very limited amount of alcohol gets you potentially higher than most psychedelics when properly d…
Bit of an aside, but a quarter of Xanax can also immediately take you out of an LSD trip.
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#19Earlier quoted context omitted.
While using GPTs to explore my own bias, I liked the re-phrasing "the chemical opens a window so that the profoundly human experience of care, safety, and novel emotion can finally get through to a brain that had walled itself off". Highlighting how the human experience is an intrinsic part of the benefit seen, but not the only part. (and I totally agree with you, alcohol is one of the strongest and also one of the l…
Indeed I suppose many are on the same opinion here… save for some super stubborn uneducated jerks who keep downvoting all my ‘Alcochol-is-likely-worse-than-LSD’ comments without even getting into reasonable argument.
Alcohol is definitely much more dangerous than LSD. The problem is that some people think LSD causes mental illness instead of the truth, which is that mentally ill people seek out substances.
90%+ of schizophrenics smoke cigarettes. Therefore, cigarettes cause schizophrenia. Nobody believes that (I don’t), I’m not sure why they think LSD makes people schizophrenic instead of schizophrenics seeking out LSD.
Re: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
#20Earlier quoted context omitted.
There’s more evidence it is than it’s not. And, yes, even people who have been super stubbornly against psychedelics only very seldom come to regret taking some. Which you cannot say for other recreational or sedating stuff at all. According to the GPTs, the LSD ranks the bottom in the chart of ‘damage done to your organism’ while alcohol tops it every time.
At the same time, using LSD once is higher risk than one night of drinking.
That is definitely 100% false. You can drink yourself to death in a night, I almost did. Woke up in the ICU after blacking out with an O2 of 70%.
You have never done LSD so I won’t even bother with my experiences on it other than you don’t lose your sense of reality, risk or self-preservation.