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CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

innovativegenomics.org

11–20 of 239 posts

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#11
The article is pretty light on details, but

> Much like other CRISPR therapies, delivery is a critical challenge, i.e., getting the large genome-cutting enzyme to all the targeted cells efficiently.

makes me think this is in vitro so far. So, years to decades away from being available for actual treatment in humans. Still good news.

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#12
post #5

What economic / political model would cause the society to prioritize this over adtech? It seems so unsettling that brilliant human minds are trying hard, every day, to figure out how to make it impossible to bypass watching ads on YouTube, instead of helping cure cancer.

There's a fair bit of frequency illusion involved here. A lot of brilliant human minds aren't, in fact, working on ad tech, and a lot of the people working on ad tech aren't, in fact, that brilliant (as evidenced by them working adversarially against their own fellow humans, for one).

There's a wide world outside big tech, Silicon Valley, and software in general. It only tends to be a bit less visible online.

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#13
post #5

What economic / political model would cause the society to prioritize this over adtech? It seems so unsettling that brilliant human minds are trying hard, every day, to figure out how to make it impossible to bypass watching ads on YouTube, instead of helping cure cancer.

The bargaining dynamics are stacked against biology researchers at every stage of their career, from needing years and years of unrelated performance to be admitted to terribly expensive programs before they can begin to do experiments, to requiring costly equipment and resources to work, to needing to work with a small number of very powerful companies. As a result, life science researchers are more price-taking tha…

The US government funds a lot of these programs, as they are obviously in the public interest. Until one man decided to stop it.

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#14
post #2

I hope this finally works out. I remember almost exactly ten years ago I got excited about one of these proposed cancer cures, tried to talk about it at lunch with my coworkers, and they laughed at me for believing.

I'm pretty optimistic. I think it's a threshold question where we need a number of basic technologies to all get over certain bars before the floodgates start to open. Over the past 1-2 decades there has been unbelievable progress at the basic technology level but most people are unimpressed because they haven't translated yet due to not individually being sufficient to cause an explosion of progress. IMO, we're star…

So we're waiting for the Apple of the medical world to take a bunch of preexisting things to be applied together in a way that makes the whole much more valuable than the pieces. Or we need all of the individual lions to come together to make the Voltron?

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#15
post #2

I hope this finally works out. I remember almost exactly ten years ago I got excited about one of these proposed cancer cures, tried to talk about it at lunch with my coworkers, and they laughed at me for believing.

I'm pretty optimistic. I think it's a threshold question where we need a number of basic technologies to all get over certain bars before the floodgates start to open. Over the past 1-2 decades there has been unbelievable progress at the basic technology level but most people are unimpressed because they haven't translated yet due to not individually being sufficient to cause an explosion of progress. IMO, we're star…

the public experiences biotechnology as decades of nothing, followed by years of everything once bottlenecks align

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#17

The article is pretty light on details, but > Much like other CRISPR therapies, delivery is a critical challenge, i.e., getting the large genome-cutting enzyme to all the targeted cells efficiently. makes me think this is in vitro so far. So, years to decades away from being available for actual treatment in humans. Still good news.

(removed)

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#18
post #5

What economic / political model would cause the society to prioritize this over adtech? It seems so unsettling that brilliant human minds are trying hard, every day, to figure out how to make it impossible to bypass watching ads on YouTube, instead of helping cure cancer.

When you reframe ads as "control of human attention" it suddenly makes a lot more sense why so many resources are poured into them.

And when you can measure how effective those ads are in changing human behavior; it's easier for businesses to spend there. As an American, I would love it if pharmaceutical companies couldn't market to consumers. It would free up money for research or lower prices.

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#19

Over on reddit people were debating whether cancer should be cured since it disproportionately affects rich people and it made me realise how far reddit has fallen. It's just a botnet now to manipulate elections.

I'm certain that is not a mainsteam opinion on reddit, but by its nature you will be able to find arbitrarily stupid opinions in individual echo chambers

Re: CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

#20

Over on reddit people were debating whether cancer should be cured since it disproportionately affects rich people and it made me realise how far reddit has fallen. It's just a botnet now to manipulate elections.

After we launched our startup, we had all sorts of folks reach out to sell their GTM services. I went with one group from Vietnam that would make engagement bait Reddit questions with some accounts, and advertise our product in the comments section with others. It was expensive but it worked
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