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Fecal transplants for autism deliver success in clinical trials (2019)

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Re: Fecal transplants for autism deliver success in clinical trials (2019)

#11
>Editor's note: Readers often ask us for follow-ups on memorable stories. What has happened to this story over the years? This article was originally published in 2019 but it has been re-edited and updated with new information current as of April 7, 2025. Enjoy!

Now that is something that should be done more often - especially in science journalism, but not only. We cruelly lack long-term vision - not only forward but backwards too.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#12
post #2

So all I gotta do is eat some poop and it will save me from becoming a handsome, funny, unique genius?

[flagged]

Source please?

I’m seeing M75/F77 w/o learning disability, and M72/F70 w/ learning disability: https://www.autism.org.uk/learn/knowledge-hub/professional-p...

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#15

What's more plausible? Did they cure low functioning autism in two years? Or did they simpily miscategorize the kids and the kids grew out of their diagnosis as they matured?

I'm guessing that the kids now have less stomachpain, constipation, and are feeling less bloated/nauseous. Thus have less voilent reactions

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#16

Earlier quoted context omitted.

Well no, what they're saying is it seems to be capable of reducing autism-related struggles and misbehavior, not that it can somehow remove autism. Truly removing autism in any meaningful way is probably impossible since the brain was trained with it since birth.

No, that appears to be the implication of this study, which frankly seems like such a large effect that I'm pretty skeptical! I'd say "where's the control group" except the claimed effect is so large that you kind of don't need one, if it's real: > Prior to the study, 83% of participants had "severe" autism. Two years later, only 17% were rated as severe, 39% as mild or moderate, and incredibly, 44% were below the cu…

That was the study without a control; for the placebo controlled study, they don't give the numbers, just say "statistically significant improvements" on several metrics.

(Without a control group, you have questions about how people of that age generally progress, and what other treatment/therapies they receive over those 2 years. The phase 1 trial was with children whose parents presumably sought ever possible way to help them, while the placebo controlled phase 2 was adults who may have plateaued.)

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#17

What's more plausible? Did they cure low functioning autism in two years? Or did they simpily miscategorize the kids and the kids grew out of their diagnosis as they matured?

Kids got into tech industry and now it’s their spouses that have to deal with their tism, instead of parents

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#18

Earlier quoted context omitted.

[flagged]

Source please? I’m seeing M75/F77 w/o learning disability, and M72/F70 w/ learning disability: https://www.autism.org.uk/learn/knowledge-hub/professional-p...

imho part of the communication problem is that a 6 year reduction actually is large, but it doesn't sound large. Smoking takes about 10 years off your life, and it's deadly in a very mechanical and understood way.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#19

Earlier quoted context omitted.

Well no, what they're saying is it seems to be capable of reducing autism-related struggles and misbehavior, not that it can somehow remove autism. Truly removing autism in any meaningful way is probably impossible since the brain was trained with it since birth.

No, that appears to be the implication of this study, which frankly seems like such a large effect that I'm pretty skeptical! I'd say "where's the control group" except the claimed effect is so large that you kind of don't need one, if it's real: > Prior to the study, 83% of participants had "severe" autism. Two years later, only 17% were rated as severe, 39% as mild or moderate, and incredibly, 44% were below the cu…

> If you are below the cutoff for mild ASD you wouldn't be diagnosed at all.

That makes sense, since ASD is a disorder classification and is mainly relevant for treatment and benefits. Plenty of autistic people are not diagnosed with ASD.

The article certainly could do more to differentiate between the autistic spectrum itself and the diagnosis of ASD, but as long as you know not to conflate the two, it seems perfectly clear to me.

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