future of protein engineering?
An idiot’s guide to lead optimisation for proteins
11–18 of 18 posts
Re: An idiot’s guide to lead optimisation for proteins
#12how many therapeutic proteins are there that aren't mabs or ~naturally occurring proteins (insulin, modified insulins, hirudin, cerezyme etc)? I can think of: etanercept
A large and rapidly growing number.
The largest commercial classes of multi-domain therapeutic proteins include the crispr (and similar) that drive gene therapies, and the chimeric antigen receptors (and similar) that drive cell therapies.
But lead optimization there look different than this page’s efforts.
Re: An idiot’s guide to lead optimisation for proteins
#13Anyone else read this as "An idiot's guide to Pb optimization for proteins," as in avoiding contaminated dietary protein isolates?
Re: An idiot’s guide to lead optimisation for proteins
#14how many therapeutic proteins are there that aren't mabs or ~naturally occurring proteins (insulin, modified insulins, hirudin, cerezyme etc)? I can think of: etanercept
A large and rapidly growing number. The largest commercial classes of multi-domain therapeutic proteins include the crispr (and similar) that drive gene therapies, and the chimeric antigen receptors (and similar) that drive cell therapies. But lead optimization there look different than this page’s efforts.
Oh yeah good point on crispr and the antibody chimeras (which etanercept is)
I guess I imagine one of the highest order obstacle to protein therapeutics to be immunogenicity, which is really hard to design around for a de Novo protein
Re: An idiot’s guide to lead optimisation for proteins
#15Anyone else read this as "An idiot's guide to Pb optimization for proteins," as in avoiding contaminated dietary protein isolates?
My first impression was that it was something about sales.
Re: An idiot’s guide to lead optimisation for proteins
#16Anyone else read this as "An idiot's guide to Pb optimization for proteins," as in avoiding contaminated dietary protein isolates?
Thank you, yes. I was very confused.
Re: An idiot’s guide to lead optimisation for proteins
#17Anyone else read this as "An idiot's guide to Pb optimization for proteins," as in avoiding contaminated dietary protein isolates?
The article at least explains what it means in literally the first sentence, which is a lot better than half the things posted on HN!
Re: An idiot’s guide to lead optimisation for proteins
#18> amino acids of which there are 20 different types
20 different types coded for, but once you get into PTMs that number goes way up.