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Peptides: where to begin?
11–20 of 431 posts
Re: Peptides: where to begin?
#12It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…
> given I eat peptides every day from my food This is briefly addressed in the article, but basically it's one thing to eat a peptide and quite another thing to inject it. Your digestive system is extremely adroit at taking peptides and proteins and breaking them down into individual amino acids, which are then absorbed via "transporters" in the gut. (e.g. SLC6A14 for glutamate and cysteine.) If you eat insulin, abso…
> > given I eat peptides every day from my food
It’s also just a silly rhetorical technique. The ability to construct a grammatical sentence of that form does not constitute a valid argument.
“Restricting nuclear material is silly given that nearly all the stuff I interact with every day contains atomic nuclei.”
Re: Peptides: where to begin?
#13It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…
> Drugs risks do not enter into the picture given the fact I can buy ammonia and bleach along with a myriad of other dangerous compounds.
This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patients heard their doctor say hydralazine and not hydroxyzine?
> As a side note more dangerous than any drug is stopping a prescription drug cold turkey.
Abject nonsense. It was very easy to stop my prescribed amoxicillin. It’s clear you don’t have any actual idea what “prescription drugs” are, in aggregate, and that should maybe inform your decision to have Big Opinions about them.
Re: Peptides: where to begin?
#14It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…
> Drugs risks do not enter into the picture given the fact I can buy ammonia and bleach along with a myriad of other dangerous compounds. This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patien…
You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement?
Yes.
Re: Peptides: where to begin?
#15> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.”
Ok, and? At worst you waste a couple hundred dollars and deem the alternative therapy not worth it and go back to your doctor but I know dozens of people at my gym that used BPC 157 and TB 500 that fixed their chronic tendon/joint issues within weeks of starting the therapy that physios couldn't fix for years.
Re: Peptides: where to begin?
#16It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…
> It seems we are treating Peptides like drugs here
That’s exactly what some biological drugs are too - peptides!
And peptides are just short chains of amino acids. Almost all the other biological drugs are just longer chains of amino acids - antibodies, enzymes, antigens, some hormones, and others.
Derek is right that the safety risks are exponentially higher when you inject peptides - you basically skip a bunch of protective mechanisms like enzymes that quickly break them down if taken orally or routes.
As a former R&D scientist there is no way I’d inject any peptide that hasn’t at least gone through a phase 1 safety study in humans. Otherwise you have no idea what it could be doing to your body.
A good example was a drug that was quickly pulled from market for causing fatal anaphylactic reactions. It wasn’t even caught in the clinical trials!
At the same time, I think people have the right to take whatever substance they want. But I worry a lot of people aren’t aware of the risks.
Re: Peptides: where to begin?
#17> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.” Ok, and? At worst you waste a couple…
You know dozens of people from a single place that have chronic tendon/joint issues?
Re: Peptides: where to begin?
#18It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…
> Drugs risks do not enter into the picture given the fact I can buy ammonia and bleach along with a myriad of other dangerous compounds. This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patien…
> This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patients heard their doctor say hydralazine and not hydroxyzine?
Weird examples. You can buy insulin without a prescription today in the USA.
In much of the world -- including almost all of Asia, Africa, and much of Eastern Europe -- you can buy almost any drug without a prescription. The only exceptions are potent CNS stimulants or narcotics, and in some rare cases antibiotics.
This is legitimately a better system. Takes out the middleman.
In the US you can get any drug if you pay $120 and recite the magic words to a telemedicine "doctor."
Re: Peptides: where to begin?
#19I really enjoyed having to wait 30 seconds for Cloudflare to let me into this website.
I think if you're a cloudflare customer they set a cookie in your browser that let's you bypass the waiting period. Just wait until next year when they show ads during the wait.
Re: Peptides: where to begin?
#20With India getting generic GLP-1s, the tech to "print" peptides will probably see costs fall off a cliff, so we're probably only looking at the tip of the iceberg with the amount of damages the reddit biohacker bros will accomplish. Men especially are feeling a lot more lonely and image-conscious and there are peptides people claim make them taller[1] or muscular[2].
1: https://www.reddit.com/r/endocrinology/comments/1jb2cce/grow...