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Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

nautil.us

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Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#11

Post by post-it »

IAmGraydon wrote: post #7
rayiner wrote: post #4

This is a very odd phrasing that makes it seem like heart attack and stroke risk are higher for those who stop taking the drug than those who never took the drug. Moreover, the effect of restarting taking the drug seems attributable to the study design. Those who took a break had higher risk at the end of the study than those who don’t. But those who took a break took the drug for less total time than those who took…

>This is a very odd phrasing that makes it seem like heart attack and stroke risk are higher for those who stop taking the drug than those who never took the drug. That does appear to be the case, according to the study.

It certainly does not. To make that claim, the study would need a control group of people who had never taken the drug. They didn't have that:

> Participants Veterans Affairs users with type 2 diabetes who started treatment with GLP-1RAs (n=132 551) or sulfonylureas (n=201 136), followed up for three years. Veterans Affairs users were defined as having at least two visits to Veterans Affairs and having used the Veterans Affairs outpatient pharmacy within a year before receiving treatment with GLP-1RAs or sulfonylureas.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#12

Post by stavros »

jryio wrote: post #10

We finally found the first morbidity signal of GLP-1s (or lack thereof). These are life changing drugs, but like plastic we'll see their effects in force within this generation: > The longer time spent off GLP-1s, the greater the risk of major cardiovascular events—up to 22 percent for those who abstained for two years.

Doesn't it make sense that, if you were taking a drug that reduces morbidity, you'll get increased morbidity if you stop it?

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#13

Post by bradleyy »

The actual study states in the summary that it's the cardiac protective improvement that reverses, not that you're worse off for having taken a GLP-1.

So yeah, when you stop taking something that protects your heart and kidneys, it stops protecting... your heart and kidneys.

There's an increasing body of work that indicates that long-term GLP use (initially higher doses for weight loss, then tapering down) retains the cardiac and kidney benefits and can actually lead to additional weight loss.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#16

Post by ErroneousBosh »

Robotbeat wrote: post #2

Kind of makes sense that stopping taking a drug that reduces heart attack and stroke risk leads to a return to the higher risk of before.

It doesn't reduce heart attack and stroke. It reduces appetite, kind of, and gives you a sore stomach while making you shit yourself inside out. All this can, with care, help contribute to weight loss.

Weight loss can reduce heart attack and stroke, but GLP-1 does not.

You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#17

Post by 0x3f »

Others have addressed the clickbait nature of the title

I'm just surprised the food industry or whoever is willing to fund FUD content that ostensibly has such an indirect effect on their bottom line.

Although I guess they spend a ton on ads which are also of dubious value, so maybe it's to be expected.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#19

Post by Aboutplants »

Also News I guess - People who pick up smoking again after a period of cessation, regain all negative effects of smoking that they previously experienced during that past smoking periods, eliminating the positive effects of the smoking cessation.
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