The biggest one (as Karpathy notes) is having skills for how to write a (slack, discord, etc) integration, instead of shipping an implementation for each.
Call it “Claude native development” if you will, but “fork and customize” instead of batteries-included platforms/frameworks is going to be a big shift when it percolates through the ecosystem.
A bunch of things you need to figure out, eg how do you ship a spec for how to test and validate the thing, make it secure, etc.
How long before OSs start evolving in this way? You can imagine Auto research-like sharing and promotion upstream of good fixes/approaches, but a more heterogenous ecosystem could be more resistant to attacks if each instance had a strong immune system.