11–20 of 57 posts
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For sources:
Overview of studies, including human:
https://www.xiahepublishing.com/m/2835-6357/FIM-2024-00006
NIH:
https://pubmed.ncbi.nlm.nih.gov/21889885/
Most recent I could find:
https://www.researchgate.net/publication/51617171_Tiliroside...
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> I can't wait to be downvoted for sharing something useful, which pretty much is par for the course on this site, i.e. altogether shallow people voting only on the basis of what they already believe in. I think you're getting downvoted more on the basis of making claims without providing credible evidence. If you really wanted to fend off the downvotes, I probably would have linked at least a handful of well-designe…
Please save me from such nonsense. Only naive people believe that. Informed people know that nothing is pursued by big corporations if there isn't big money in it. And there isn't since it's a cheap common product produced around the world.
As a further example, mRNA tech was intentionally rejected, ignored, and not developed for decades. Meanwhile, the false beta-amyloid theory of Alzheimers was purused for over a decade even though it was very clear informed people that it's a dumb theory. People are not as smart as you think they are, not even close.
As for the studies, PMID 27980600 and DOI 10.1016/j.hermed.2024.100875 are a fair start, although the latter is paywalled.
Earlier quoted context omitted.
The problem with chronic cold exposure is that it makes one very hungry, a lot hungrier than usual, with the compensatory calorie consumption risking negating the intended benefit.
Hunger, like cold exposure, is an uncomfortable but transient signal. In many cases it peaks and subsides without requiring immediate action, especially once the body adapts. Anecdotally, my first 72-hour fast was revealing. Around the 48-hour mark my body aggressively signaled hunger, esp. for sugary foods. By the third day, however, hunger largely subsided, and at break I wasn’t hungry at all. For the following wee…
Earlier quoted context omitted.
in all respect sorry this is wrong. this is a broad misinformation. It can enhance but also supresse cancer dependig of soo much we dont know yet enough to know if fasting is beneficial or dangerous. https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.5577 edit:// and the article has imho nothinh to do with autophagy. Its about beige fat cells eating stuff away from cancer not autophagy wich happened in the innerce…
The paper you posted is just a review on autophagy and cancer that doesn’t contradict anything I stated. It is a mistake to conflate autophagy, calorie restriction, and cold exposure as necessarily biologically identical, which your comment seems to imply. I was only raising questions this research and discussion made me curious about, not making any concrete claims. Although the idea of calorie restriction as a canc…
That was the part that confused me.
"If it does negate the benefit than that would suggest that the entire benefit from the beige fat is from putting the body in a calorie deficit, and you would then expect the exact same effectiveness from calorie restriction"
As far as I understood the paper its beige fat that can eat away food from cancer and not white fat. And afaik calorie restriction doesnt augment beige fat. My error was thinking you meant calorie restriction while having white fat but you meant with beige fat? And yes this makes sense.
And I thinked autophagy because this is the main "thing" happenkng while fasting which is not burning body fuel
thanks for the answer
Earlier quoted context omitted.
The problem with chronic cold exposure is that it makes one very hungry, a lot hungrier than usual, with the compensatory calorie consumption risking negating the intended benefit.
Hunger, like cold exposure, is an uncomfortable but transient signal. In many cases it peaks and subsides without requiring immediate action, especially once the body adapts. Anecdotally, my first 72-hour fast was revealing. Around the 48-hour mark my body aggressively signaled hunger, esp. for sugary foods. By the third day, however, hunger largely subsided, and at break I wasn’t hungry at all. For the following wee…
Edit: for those wanting to try this lifestyle, everybody is different. do your own research before jumping into regular fasting or even cold showers. Max time without food I did was 6 days, since then t it he max is 72 hours. Do blood work regularly and if you drink coffee be aware that caffeine withdraws are painful.
Earlier quoted context omitted.
The paper you posted is just a review on autophagy and cancer that doesn’t contradict anything I stated. It is a mistake to conflate autophagy, calorie restriction, and cold exposure as necessarily biologically identical, which your comment seems to imply. I was only raising questions this research and discussion made me curious about, not making any concrete claims. Although the idea of calorie restriction as a canc…
you are right now I better understand what you meant. That was the part that confused me. "If it does negate the benefit than that would suggest that the entire benefit from the beige fat is from putting the body in a calorie deficit, and you would then expect the exact same effectiveness from calorie restriction" As far as I understood the paper its beige fat that can eat away food from cancer and not white fat. And…
Yes, autophagy does ramp up during fasting, but it's just one of a number of different physiological changes that occur during fasting.
> Nguyen moved to UT Austin to start his own lab in January 2024 but passed away suddenly in November before he could finish the final experiments. The paper, of which he is the first author, is dedicated to him. That's sad. I hope someone picks up the torch. The research sounds very promising.
> Nguyen moved to UT Austin to start his own lab in January 2024 but passed away suddenly in November before he could finish the final experiments. The paper, of which he is the first author, is dedicated to him. That's sad. I hope someone picks up the torch. The research sounds very promising.
Earlier quoted context omitted.
Hunger, like cold exposure, is an uncomfortable but transient signal. In many cases it peaks and subsides without requiring immediate action, especially once the body adapts. Anecdotally, my first 72-hour fast was revealing. Around the 48-hour mark my body aggressively signaled hunger, esp. for sugary foods. By the third day, however, hunger largely subsided, and at break I wasn’t hungry at all. For the following wee…
Ultimately, regardless of how one feels, you need to (will) maintain calorie balance in the long term, and cold exposure requires a higher calorie intake.
More generally, it seems inconsistent to assume someone can voluntarily tolerate significant cold discomfort while being unable to manage similar degrees of hunger discomfort.
Earlier quoted context omitted.
The problem with chronic cold exposure is that it makes one very hungry, a lot hungrier than usual, with the compensatory calorie consumption risking negating the intended benefit.
Hunger, like cold exposure, is an uncomfortable but transient signal. In many cases it peaks and subsides without requiring immediate action, especially once the body adapts. Anecdotally, my first 72-hour fast was revealing. Around the 48-hour mark my body aggressively signaled hunger, esp. for sugary foods. By the third day, however, hunger largely subsided, and at break I wasn’t hungry at all. For the following wee…
It’s like my brain has retrained itself to ‘just get over it’. It was quite something