I was impressed by the clarity and terseness of this little article.
Is it common practice in the case of scientific articles coming from Japan?
Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
11–20 of 144 posts
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#12100% response, zero side effects? This sounds like world changing news. Can anyone with domain expertise explain the catch, if any?
The catch is that there are thousands of promising therapies in animal models/pre-human testing. A very very tiny fraction of them will ever make it to market for a variety of both good and not-good reasons.
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#13Just FYI, this study was done in mice.
Thanks, we've inmiced the title.
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#14Just FYI, this study was done in mice.
I would be in favor of adding a standardized [in mice] to the titles of all HN submissions about medical breakthroughs. Most of them end up being in mice and many do not reproduce in humans. It would help, at a glance, to know how significant a study's results are.
Or alternatively, some marker to indicate the presence of an “only in mice” comment
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#15100% response, zero side effects? This sounds like world changing news. Can anyone with domain expertise explain the catch, if any?
The catch is that there are thousands of promising therapies in animal models/pre-human testing. A very very tiny fraction of them will ever make it to market for a variety of both good and not-good reasons.
What's the difference between a good and not-good reason to not go to market?
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#16[flagged]
I know hearing this gets old, however, please review sources outside of LLMs for accuracy. LLMs take a whole bunch off stuff from all over the internet and distill it down to something you can consume. Those sources include everything from reddit to a certain de-wormer that folks still think treats COVID (side note: I've a few long COVID victims in a support group I am in, and they are not happy about the disinfo that was spread, at any rate)...LLMs/"AI" does not and cannot innovate, it can only take all existing information it knows, mash it all together, and present you with a result according to what the model is trained on.
I'm not against AI summaries being on HN, however, users should verify and cite sources so others can verify.
However, I'm just a normal nerd that wants to fact check stuff. Perhaps I'm wrong in wanting to do this. We'll see.
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#17Earlier quoted context omitted.
The catch is that there are thousands of promising therapies in animal models/pre-human testing. A very very tiny fraction of them will ever make it to market for a variety of both good and not-good reasons.
What's the difference between a good and not-good reason to not go to market?
A lot of potential treatments are too easily available and can't be patented. If a big pharma company can't make massive profit from it, they won't bother bringing it to market. Consider that a not-good reason.
Other treatments may eventually prove to have too many serious negative side effects. That's a good reason to abandon them.
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#18I was impressed by the clarity and terseness of this little article. Is it common practice in the case of scientific articles coming from Japan?
https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2...
Link to the research article.
Are you referring to the news release?
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#19Just FYI, this study was done in mice.
As a rule of thumb, it’s best to assume that all studies like this are in mice or rats unless the headline specifically says “in human trials”.
Murine studies are a dime a dozen and therefore it’s the default assumption when reading research papers. When human trials commence the fact that it’s in humans is a big part of the research and therefore paper titles.
Re: Gut bacteria from amphibians and reptiles achieve tumor elimination in mice
#20Earlier quoted context omitted.
What's the difference between a good and not-good reason to not go to market?
A lot of potential treatments are too easily available and can't be patented. If a big pharma company can't make massive profit from it, they won't bother bringing it to market. Consider that a not-good reason. Other treatments may eventually prove to have too many serious negative side effects. That's a good reason to abandon them.
Why would a China or India care if it were a viable treatment? Unless a country wants to use their population as lab rats, it takes money and scientists to actually confirm a treatment is safe and effective.