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Polylaminin, a drug considered capable of reversing spinal cord injury

www1.folha.uol.com.br

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Re: Polylaminin, a drug considered capable of reversing spinal cord injury

#11

[flagged]

Hey FYI, this isnt the place for that type of comment. This isn't Reddit, and we don't want it to become such.

Unnuanced, potentially inflammatory quips about a vaguely related current political situation just aren't appropriate here.

There are plenty of ways to express the same sentiment without resorting to the type of commentary that is common elsewhere.

I encourage you to read the community guidelines for HN.

Re: Polylaminin, a drug considered capable of reversing spinal cord injury

#12
post #8
post #4

Paper: https://journals.plos.org/plosone/article?id=10.1371/journal...

I think it's actually this one, or perhaps a new one after it: https://www.medrxiv.org/content/10.1101/2024.02.19.24301010v...

I find this part most interesting: "Three participants (2, 7, 8) regained motor control. i.e., converted to AIS C or D, at the 1-month examination. Other three (4, 5, 6) converted to grade C after 3 months. In the present study we observed that, in contrast to the expected baseline conversion of 15%, 75% (6/8) of the participants regained voluntary motor control after polylaminin treatment. If we consider only those participants that reached discharge, the proportion increases to 100% (6/6)."

Re: Polylaminin, a drug considered capable of reversing spinal cord injury

#13
post #7

Earlier quoted context omitted.

That paper is an in vitro demonstration whereas the OP article seems to imply they tested on actual patients?

Yes, it was tested on patients. @ bfdrummond on Instagram was the first one - he is now almost 100% recovered

Do we know of other patients?

Sometimes drug and medical device companies will gag patients with non-disparagement agreements, while letting the success stories post freely on social media to promote their product/procedure/etc.

Re: Polylaminin, a drug considered capable of reversing spinal cord injury

#14
This is fantastic news.

A good friend of mine spent years doing research at Caltech in basically trying to bridge the severed part of the spinal column with electrodes. In mice that is.

The department got lots of $ from the Christopher & Dana Reeve Foundation to help them in said research.

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