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Mirror bacteria research poses significant risks, scientists warn

the-scientist.com

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Re: Mirror bacteria research poses significant risks, scientists warn

#11
> The trouble with mirror cells is that they could probably evade most of the barriers that keep ordinary organisms in check. To fight off pathogens, for example, our bodies must first detect them with molecular sensors.

> Those sensors can only latch onto left-handed proteins or right-handed DNA and RNA. A mirror cell that infected lab workers might spread through their bodies without triggering any resistance from their immune systems.

It’s clear that RNA wouldn’t be complementary to mirror RNA, but antibody binding is more complex than RNA hybridization. Is it a foregone conclusion that antibodies couldn’t bind to mirror antigens?

(Degrading mirror proteins, as mentioned elsewhere in OP, does seem like a bigger obstacle.)

Re: Mirror bacteria research poses significant risks, scientists warn

#13

How does a research ban even work? It seems to me that at some point someone is going to research it; at which point everyone is left flat footed by having not researched it.

We don’t research what happens when a child falls out of a plane and nobody feels like we’re falling behind for it.

Re: Mirror bacteria research poses significant risks, scientists warn

#14
I don’t understand why the innate immune response wouldn’t default to attacking an organism made of chiral molecules, since it attacks anything it doesn’t recognise.

And while the adaptive immune response might not immediately recognise a novel organism, is there something that would prevent it ever adapting?

Re: Mirror bacteria research poses significant risks, scientists warn

#15

How does a research ban even work? It seems to me that at some point someone is going to research it; at which point everyone is left flat footed by having not researched it.

We don’t research what happens when a child falls out of a plane and nobody feels like we’re falling behind for it.

but would a ban really stop somebody from trying?

Re: Mirror bacteria research poses significant risks, scientists warn

#17
Searching HN for "mirror cells", I see at least 1 article warning of the dangers from more than 10 years ago. So, this has been a thing for a while. Any biologists here that can chime in on just how big of a risk they do pose? Is there a general consensus throughout the community that this research should end? Is this something that could be developed for bio-terrorism? Should work be started on developing mirror immune system cells, just in case?

Re: Mirror bacteria research poses significant risks, scientists warn

#19
post #3
post #2

The potential for unchecked "growth" and potentially fatal infection vaguely reminds me of the terrifying aspects of prion based diseases. Thanks for giving me another theoretical nightmare scenario to worry about in the back of my mind! :-) Related: Technical Report on Mirror Bacteria: Feasibility and Risks (stanford.edu) https://news.ycombinator.com/item?id=42403394

Grey goo. https://en.m.wikipedia.org/wiki/Gray_goo AI paperclips https://cepr.org/voxeu/columns/ai-and-paperclip-problem Prions getting into food supply Nuclear holocaust. I’m definitely not sleeping tonight. I can see why Gen Z is thinking not to have kids…

Environmental collapse due to climate change is way, way more likely than any of those.
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