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FDA Approves Drug with New Mechanism of Action for Treatment of Schizophrenia

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Re: FDA Approves Drug with New Mechanism of Action for Treatment of Schizophrenia

#11
post #5

It's interesting that it's priced at $1850/month wholesale. If TFA is to be believed, schizophrenia is quite common so the market is vast and the usual excuses of "price has to be high to recoup R&D because of low demand" doesn't seem like it would apply. A mere 1M worldwide prescriptions (there's 6x that amount of people with schizophrenia in America alone) means 22 billions per year raw revenue.

They are not all going to get it right away, there are competitive drugs, it will first be used for patients who can’t tolerate current drugs. (Actually quite a few of them) A lot of people with schizophrenia and related conditions are untreated. I know someone right now who is in her 40s and about to lose her housing who almost certainly has schizophrenia (sure has the thought disorder, if we want to pick her up to…

> and doesn’t believe there is anything wrong about her.

that is anosognosia: https://en.wikipedia.org/wiki/Anosognosia

Re: FDA Approves Drug with New Mechanism of Action for Treatment of Schizophrenia

#12

See https://en.wikipedia.org/wiki/Xanomeline/trospium_chloride It’s interesting to me that this is a combination medicine because the atypical antipsychotics (say https://en.wikipedia.org/wiki/Quetiapine ) are “polypharmacy in a single molecule” in that they bind to both dopamine and serotonin receptors which cancel out terrible side effects such as tardive dyskinesia caused by earlier antipsychotics that work on the…

[deleted]

Re: FDA Approves Drug with New Mechanism of Action for Treatment of Schizophrenia

#13
post #5

It's interesting that it's priced at $1850/month wholesale. If TFA is to be believed, schizophrenia is quite common so the market is vast and the usual excuses of "price has to be high to recoup R&D because of low demand" doesn't seem like it would apply. A mere 1M worldwide prescriptions (there's 6x that amount of people with schizophrenia in America alone) means 22 billions per year raw revenue.

How does this treatment compare to amisulpride or CBD for schizophrenia? https://www.google.com/search?q=amisulpride+cbd https://scholar.google.com/scholar?hl=en&q=amisulpride%20cbd...

Ask a medical researcher with domain knowledge, not someone on HN.
Post reply on HN