It keeps coming back to metabolism being the entire key to all types of cancer.
Lactate helps cancer cells resist chemotherapy
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Re: Lactate helps cancer cells resist chemotherapy
#12It keeps coming back to metabolism being the entire key to all types of cancer.
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Re: Lactate helps cancer cells resist chemotherapy
#13Earlier quoted context omitted.
> Does the paper imply that any exercise is bad? How did you leap from (anaerobic) exercise to just exercise?
I guess I didn’t process it. Just got back from a 3 mile walk and had my first chemotherapy yesterday. A little panic set in. Sounds like walking is still good. Thanks
jeez I cant imagine I'd be reading anything on cancer once i started treatement... that would cause me to second guess everything.
good luck to you fellow hacker.
Re: Lactate helps cancer cells resist chemotherapy
#14This is all I can read. Does the paper imply that any exercise is bad? “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mecha…
Lactate accumulates in the body only during a high intensity exercise, which generates lactate faster than it can be consumed by oxidation (like a sprint for up to 400 m). When the intensity of an exercise is low enough that you could sustain it for much more than a few minutes continuously, there should be no increased amount of lactate in the body.
I want to expand a bit on your last statement. It is generally true but there is some important nuance I'd like to add. There may be some increased lactate temporarily but it will be minimal for aerobic exercise. It takes at least 2 minutes from a resting state for the body to reach VdotO2max. This means that even during aerobic exercise, you will be using at least some anaerobic energy production initially if you were not already warmed up. This is one reason why doing a warmup is a good idea.
Re: Lactate helps cancer cells resist chemotherapy
#15It keeps coming back to metabolism being the entire key to all types of cancer.
You should read “Tripping over the Truth: The Metabolic Theory of Cancer”[0]
Re: Lactate helps cancer cells resist chemotherapy
#16It keeps coming back to metabolism being the entire key to all types of cancer.
Do hypothyroidism or hyperthyroidism patients show fewer cancer cases?
Re: Lactate helps cancer cells resist chemotherapy
#17Earlier quoted context omitted.
> Does the paper imply that any exercise is bad? How did you leap from (anaerobic) exercise to just exercise?
I guess I didn’t process it. Just got back from a 3 mile walk and had my first chemotherapy yesterday. A little panic set in. Sounds like walking is still good. Thanks
Fasting before chemo is probably also good, but you can read about its applicability for your case.
Re: Lactate helps cancer cells resist chemotherapy
#18This is all I can read. Does the paper imply that any exercise is bad? “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mecha…
I’m reading Silent Spring, which was published in 1962. We already knew then that sugar to ATP transition in the mitochondria is a multiple step process to oxidize the sugar and produce ATP, and different pollutants or injuries could interrupt any of those steps and cause major problems.
And relevant to this conversation: we knew that a breakdown in these stages of cellular metabolism could result in tumors.
Re: Lactate helps cancer cells resist chemotherapy
#19Earlier quoted context omitted.
I guess I didn’t process it. Just got back from a 3 mile walk and had my first chemotherapy yesterday. A little panic set in. Sounds like walking is still good. Thanks
Fasting before chemo is probably also good, but you can read about its applicability for your case.
Has this been incorporated into protocols or is this still fringe?
Re: Lactate helps cancer cells resist chemotherapy
#20Earlier quoted context omitted.
Fasting before chemo is probably also good, but you can read about its applicability for your case.
Has this been incorporated into protocols or is this still fringe?
That's entirely the wrong set of questions to ask. It is scientifically validated which is what matters as far as the truth is concerned.