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Gene therapy restores hearing to children with inherited deafness

cosmosmagazine.com

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Re: Gene therapy restores hearing to children with inherited deafness

#11

Post by dfadsadsf »

Something1234 wrote: post #3

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

In vitro fertilization (IVF) combined with preimplantation genetic screening (PGS) is becoming increasingly mainstream. This advanced technique allows us to select embryos with healthy genes, thereby ensuring that babies are born healthy or at least reducing the risk of genetic diseases. Very expensive in US but is getting very affordable in Eastern Europe and Asia.

Another alternative is selective abortions after early genetic testing (though ethic and morale concerns here are huge).

Re: Gene therapy restores hearing to children with inherited deafness

#12

Post by dyauspitr »

gota wrote: post #2

This stuff seems miraculous. > "Through minimally invasive surgery, Shu injected adeno-associated virus (AAV) engineered to carry and deliver functioning copies of the human OTOF transgene, into the children’s inner ears. " Can't read that and not get curious, excited, for the future. Congratulations to all those involved in the research and thanks to all who contributed to it - including all taxpayers if public fund…

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too.

Hopefully in the next 50 years but that’s wishful thinking.

Re: Gene therapy restores hearing to children with inherited deafness

#13

Post by teaearlgraycold »

Something1234 wrote: post #3

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

Damn. Might as well just kill ourselves because our children inherit our problems. My parents need glasses, I’ll need glasses. Fuck.

/s

Re: Gene therapy restores hearing to children with inherited deafness

#14

Post by roygbiv2 »

Gene therapy is coming on well. Hopefully it'll help my kid when he's older. From what I'm being told, the gene that effects him is very large and difficult to fit into the viruses they use for gene therapy. My understanding is very limited so I could be very wrong here.

Re: Gene therapy restores hearing to children with inherited deafness

#15

Post by kevin_thibedeau »

dyauspitr wrote: post #12
gota wrote: post #2

This stuff seems miraculous. > "Through minimally invasive surgery, Shu injected adeno-associated virus (AAV) engineered to carry and deliver functioning copies of the human OTOF transgene, into the children’s inner ears. " Can't read that and not get curious, excited, for the future. Congratulations to all those involved in the research and thanks to all who contributed to it - including all taxpayers if public fund…

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too. Hopefully in the next 50 years but that’s wishful thinking.

There are potential serious downsides if these inserted genes end up on a different chromosome than normal and become carried by gametes to offspring who may suffer from overexpression.

Re: Gene therapy restores hearing to children with inherited deafness

#16

Post by antegamisou »

dyauspitr wrote: post #12
gota wrote: post #2

This stuff seems miraculous. > "Through minimally invasive surgery, Shu injected adeno-associated virus (AAV) engineered to carry and deliver functioning copies of the human OTOF transgene, into the children’s inner ears. " Can't read that and not get curious, excited, for the future. Congratulations to all those involved in the research and thanks to all who contributed to it - including all taxpayers if public fund…

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too. Hopefully in the next 50 years but that’s wishful thinking.

We need to keep away biotech OpenAI-wannabes apparently.

Re: Gene therapy restores hearing to children with inherited deafness

#18

Post by dyauspitr »

kevin_thibedeau wrote: post #15
dyauspitr wrote: post #12

Earlier quoted context omitted.

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too. Hopefully in the next 50 years but that’s wishful thinking.

There are potential serious downsides if these inserted genes end up on a different chromosome than normal and become carried by gametes to offspring who may suffer from overexpression.

I presume at the point we can generate CAD like designer gene modifications, overexpression would just be another problem that can be fixed by more modification.

Re: Gene therapy restores hearing to children with inherited deafness

#20

Post by roywiggins »

pfannkuchen wrote: post #7
david38 wrote: post #4

Earlier quoted context omitted.

We have this already. As a species we are susceptible to many diseases which we have to take vaccines for, every generation.

I don't think susceptibility to viral diseases like measles is typically regarded as a genetic defect, is it? Any more than being flammable is a genetic defect, anyway.

There are a few people who are genetically immune to HIV, but it's quite rare. Whether everyone else is therefore genetically deficient is sort of a matter of perspective, I suppose.

https://en.m.wikipedia.org/wiki/Innate_resistance_to_HIV

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