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Viral DNA in the human genome linked to major psychiatric disorders
11–20 of 141 posts
Re: Viral DNA in the human genome linked to major psychiatric disorders
#12Earlier quoted context omitted.
Do you blog? I'd love to read more, and I really enjoy your writing style.
I found that way of writing terribly arrogant and annoying, like a smart 15-year-old.
I rather enjoy talking to smart 15 year olds. They're curious about the world and more likely to have fresh takes. What's not to like?
Re: Viral DNA in the human genome linked to major psychiatric disorders
#13Earlier quoted context omitted.
Would it be possible to consider them separately though? Like maybe it will turn out that say 10% of them are beneficial, 65% of them are neutral (either they do nothing at all or a mixture of benefit and harm), and 25% are slightly bad for us (can't be too harmful or we would have already known ig).
Delivering gene therapies into brain cells is a non-trivial task. Also, there's alternatives to cutting the original sequence out; you can also dampen the transcribed RNA with downstream therapies.
I thought this was more of a 'designer babies' suggestion than a 'mess with the source code after it's finished compiling' one.
Re: Viral DNA in the human genome linked to major psychiatric disorders
#14This kind of science leaves me with lots and lots of questions.
E.g.: As our understanding of DNA progresses, and we link more and more of it to different traits, will we eventually get into a situation where a swab on the water glass tells potential employer much more than the interview?
Or: imagine that in addition to the discovery "viral DNA in the human genome linked to major psychiatric disorders" there's a discovery that "this viral DNA is much more prevalent in [a certain population]". What will be the consequences of this?
Re: Viral DNA in the human genome linked to major psychiatric disorders
#15So uhm, can/should we start cutting these proviruses(?) out of our genomes? Unintended consequences?
I love humans, we discover a new interesting thing, think we're big boys who understand everything there is to understand and that we can shape things to our will with no adverse consequences
That's how we got asbestos in walls, lead in gas/paint, freon, pfas, &c. The same story over and over and over again. But sure go ahead and start slicing our dna, what could possibly go wrong?
Re: Viral DNA in the human genome linked to major psychiatric disorders
#16Maybe someone can provide a better understanding, I'm a clinical psych doctoral student, but this is outside my area of research + methods.
On very quick review, it looks like there are is significant association between HERV genetic factors and specific diagnoses given PIP. However, what's not clear to me is effect size or correlation coefficient.
I'm not sure if I'm missing this or it's not reports. There might be a relationship, but at a very small percentage.
Re: Viral DNA in the human genome linked to major psychiatric disorders
#17So uhm, can/should we start cutting these proviruses(?) out of our genomes? Unintended consequences?
I love humans, we discover a new interesting thing, think we're big boys who understand everything there is to understand and that we can shape things to our will with no adverse consequences That's how we got asbestos in walls, lead in gas/paint, freon, pfas, &c. The same story over and over and over again. But sure go ahead and start slicing our dna, what could possibly go wrong?
Of course there are risks. The question is how big the risk is, and how well we can mitigate it.
Re: Viral DNA in the human genome linked to major psychiatric disorders
#18Earlier quoted context omitted.
Do you blog? I'd love to read more, and I really enjoy your writing style.
I found that way of writing terribly arrogant and annoying, like a smart 15-year-old.
Thank you for your honest perspective! Sincere thanks. I guess it’s the approach of 45 years of age that I am unfazed.
I’ve heard a number of times that my persona in writing absolutely does not make sense to some people – until they meet me.
I think I can assure you of my non-arrogance. The wry, cynical, even flippant? note is directed at myself. My limitations and recklessness and jumping to conclusions.
If you find me, I offer you a cup of coffee. In return I’d like an equally honest reassessment.
(Full sincerity here!)
edit; Ah. Also. Another thing I can assure you of: Sometimes, afterwards, I come across my own writing and find it awful. in exactly that way. Like an annoying and arrogant 15yo had written it. Which is my greatest fear. To become that 15yo again, the person I certainly was for a decade or so. (Starting at around age 12-ish.) I knew I was annoying but I didn’t know I was arrogant. It turns out the two were related.
Re: Viral DNA in the human genome linked to major psychiatric disorders
#19This kind of science leaves me with lots and lots of questions. E.g.: As our understanding of DNA progresses, and we link more and more of it to different traits, will we eventually get into a situation where a swab on the water glass tells potential employer much more than the interview? Or: imagine that in addition to the discovery "viral DNA in the human genome linked to major psychiatric disorders" there's a disc…
> where a swab on the water glass tells potential employer much more than the interview?
More likely RNA, because DNA doesn't mean traits are actually active. Also, only if you believe nature>>nurture and that experience doesn't matter. The level of understanding of your issues and how to counteract them makes a difference too.
In practice you probably want someone with issues they know how to cope with and lots of enthusiasm for $job rather than a rando with great generic potential and hating every minute at work.
Re: Viral DNA in the human genome linked to major psychiatric disorders
#20This kind of science leaves me with lots and lots of questions. E.g.: As our understanding of DNA progresses, and we link more and more of it to different traits, will we eventually get into a situation where a swab on the water glass tells potential employer much more than the interview? Or: imagine that in addition to the discovery "viral DNA in the human genome linked to major psychiatric disorders" there's a disc…
What makes you think this hasnt already been done?