11–20 of 29 posts
[flagged]
You might find Pollan’s “How to Change Your Mind” a good read to get some background of fear uncertainty and death/dread around some drugs and how it’s tainted a lot of perception over the years.
MindMed’s MM120 is set to compete with such drugs as Spravato, a type of ketamine that, for now, is the only FDA-approved nasal spray for treatment-resistant depression. When Spravato came to market in 2019, its manufacturer Johnson & Johnson charged $4,720 to $6,785 per dose. These prices are ridiculous.
AFAIK a "hit" of LSD is like IDK what the street price of a ketamine dose is but I would be surprised if it was more than $20.
Then again you can't bill those to an insurance company...
[flagged]
Every form of medication has associated risk and there are horrific anecdotes for everything. The key is to get more probable benefit than probable detriment. If the risk for a particular medication is unusually high then the problem it's likely to help with has to be commensurately severe.
Curious if someone more familiar with this space could comment on what exactly is meant when it says the drug in question -- MM120 -- has been "pharmacologically optimized" from the base LSD? I know the "real" vs "synthetic" distinction is kind of silly w.r.t. psychedelics in general (especially so with LSD since it's only ever been synthetic), but understanding exactly how the new crop of drugs actually differ from…
it seems like MM120 is literally just the "optimal dose" of the tartate salt (the normal salt LSD is co-crystallized with) of LSD in a pill. it doesn't seem like there's any special delivery device, nor is it any sort of prodrug nor is it a deuterated analogue.
[flagged]
Different drugs are useful in different stages of life. Please don’t give LSD to children.
Curious if someone more familiar with this space could comment on what exactly is meant when it says the drug in question -- MM120 -- has been "pharmacologically optimized" from the base LSD? I know the "real" vs "synthetic" distinction is kind of silly w.r.t. psychedelics in general (especially so with LSD since it's only ever been synthetic), but understanding exactly how the new crop of drugs actually differ from…
As far as shorter trips, Compass Pathways is testing psilocybin for depression. Another company, Field Trip Health, was developing an analog of psilocybin with a shorter trip duration, but it doesn't seem to be progressing past Phase 1 trials.
Different drugs are useful in different stages of life. Please don’t give LSD to children.
My understanding is that the brain undergoes important development until around 25 years old, so it's best to push drug use to after. If someone insists on doing something earlier, before 16 years old is probably a terrible idea.
[flagged]
i'm not sure about that particular case, but consuming LSD while on lithium (commonly prescribed for bipolar disorder) essentially guarantees an acute episode of psychosis and possibly seizures so I wonder if that particular individual was on lithium at the time.
Curious if someone more familiar with this space could comment on what exactly is meant when it says the drug in question -- MM120 -- has been "pharmacologically optimized" from the base LSD? I know the "real" vs "synthetic" distinction is kind of silly w.r.t. psychedelics in general (especially so with LSD since it's only ever been synthetic), but understanding exactly how the new crop of drugs actually differ from…
MM120 is chemically identical to LSD. The "optimization" they claim is just a regulatory workaround aimed at maintaining patent protection for longer. As far as shorter trips, Compass Pathways is testing psilocybin for depression. Another company, Field Trip Health, was developing an analog of psilocybin with a shorter trip duration, but it doesn't seem to be progressing past Phase 1 trials.