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Men on Viagra may reduce their Alzheimer's risk – study

bbc.co.uk

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Re: Men on Viagra may reduce their Alzheimer's risk – study

#11

Post by Log_out_ »

jgrahamc wrote: post #8
finnjohnsen2 wrote: post #6

Please let's make a downvote free thread for throwing jokes a round on this topic. We need this freedom for such a topic trending on HN. There is so much low hanging fruit and we're all thinking of several I suspect. My initial thought was in the lane of 'drug is affecting one more head than intended', but it's missing some refinement I'll admit

No, let's not. We don't "need this freedom". And we're not "all thinking of several". Grow up.

Childish mindset is more likely to innovate though. For hacking ones environment, growing up makes one ineffective. Then again, so does low effort Dopamin bombarding content consumption. Then again it creates a nice little pocket universe meta discussion.

Re: Men on Viagra may reduce their Alzheimer's risk – study

#12

Post by finnjohnsen2 »

jgrahamc wrote: post #8
finnjohnsen2 wrote: post #6

Please let's make a downvote free thread for throwing jokes a round on this topic. We need this freedom for such a topic trending on HN. There is so much low hanging fruit and we're all thinking of several I suspect. My initial thought was in the lane of 'drug is affecting one more head than intended', but it's missing some refinement I'll admit

No, let's not. We don't "need this freedom". And we're not "all thinking of several". Grow up.

But it's a drug already helping many elderly stay sexually active, and now they also remember with who. This is great news. And kinda funny.

Re: Men on Viagra may reduce their Alzheimer's risk – study

#13

Post by jgrahamc »

finnjohnsen2 wrote: post #12
jgrahamc wrote: post #8

Earlier quoted context omitted.

No, let's not. We don't "need this freedom". And we're not "all thinking of several". Grow up.

But it's a drug already helping many elderly stay sexually active, and now they also remember with who. This is great news. And kinda funny.

And you're welcome to find it funny. But I don't welcome a long thread of Reddit-style stupid jokes about this here. If I wanted that I'd go to Reddit.

Re: Men on Viagra may reduce their Alzheimer's risk – study

#14

Post by A_D_E_P_T »

bun_terminator wrote: post #4

The study is called "Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease" and published in "Neurology", for reference. It's open access, link: https://doi.org/10.1212/WNL.0000000000209131

All in all, it's not too surprising.

The paper mentions neuroprotective effects, but it has been known for a while that nearly all types of PDE inhibitor can boost cognitive function, which has led to some interest in them as nootropics: https://pubmed.ncbi.nlm.nih.gov/25464010/

There has been some interest in PDE5 inhibitors, specifically, as treatments for Alzheimer's: https://www.sciencedirect.com/science/article/abs/pii/S03619...

And, in a 20 year old paper, a PDE5 inhibitor appears to have direct effects on memory consolidation in an animal model: https://pubmed.ncbi.nlm.nih.gov/15312986/

So, yeah, if I fancied myself at risk for dementia, I don't think it would be unwise to take viagra or sildenafil as a precautionary neuroprotective measure.

Re: Men on Viagra may reduce their Alzheimer's risk – study

#15

Post by andy_ppp »

Maybe the brain get's worse at clearing stuff out as your blood vessels age and viagra is opening them up? Cardio, weight lifting, HIIT, sauna, healthy balanced diet, yoga, inversions, beetroot juice, citrulline malate, etc. could all be worthy of investigation ;-)

Re: Men on Viagra may reduce their Alzheimer's risk – study

#16

Post by Xeyz0r »

andy_ppp wrote: post #15

Maybe the brain get's worse at clearing stuff out as your blood vessels age and viagra is opening them up? Cardio, weight lifting, HIIT, sauna, healthy balanced diet, yoga, inversions, beetroot juice, citrulline malate, etc. could all be worthy of investigation ;-)

Physical activity and a healthy lifestyle positively impact the body in any case. I would even add psychological well-being and, so to speak, harmony with oneself

Re: Men on Viagra may reduce their Alzheimer's risk – study

#17

Post by gunnihinn »

finnjohnsen2 wrote: post #6

Please let's make a downvote free thread for throwing jokes a round on this topic. We need this freedom for such a topic trending on HN. There is so much low hanging fruit and we're all thinking of several I suspect. My initial thought was in the lane of 'drug is affecting one more head than intended', but it's missing some refinement I'll admit

I read Playboy for the stories and take Viagra for the memories.

Re: Men on Viagra may reduce their Alzheimer's risk – study

#18

Post by m463 »

andy_ppp wrote: post #15

Maybe the brain get's worse at clearing stuff out as your blood vessels age and viagra is opening them up? Cardio, weight lifting, HIIT, sauna, healthy balanced diet, yoga, inversions, beetroot juice, citrulline malate, etc. could all be worthy of investigation ;-)

also, sex.

(more seriously, anything that improves your circulation will probably help with alzheimers, plus good sleep)

Re: Men on Viagra may reduce their Alzheimer's risk – study

#19

Post by verisimi »

andy_ppp wrote: post #15

Maybe the brain get's worse at clearing stuff out as your blood vessels age and viagra is opening them up? Cardio, weight lifting, HIIT, sauna, healthy balanced diet, yoga, inversions, beetroot juice, citrulline malate, etc. could all be worthy of investigation ;-)

Perhaps it helps with the removal of adjuvants from the body.
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