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Chronic Buckyball Administration Doubles Rat Lifespan

extremelongevity.net

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Re: Chronic Buckyball Administration Doubles Rat Lifespan

#11

Post by Udo »

frogly wrote: post #10

at the risk of sounding strange, is this or anything similar available to buy anywhere?

It is being produced for research purposes, so I guess you could ask at your local university lab where they sourced it. But caution is in order: the experiment described in the article was intended to find out about the toxicity of BF C60. Given that many of its chemically-similar relatives are indeed highly toxic, it's probably not a good idea to ingest this stuff yet. Six rats don't prove this substance is harmless.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#15

Post by fleitz »

This doubles median lifespan, not absolute lifespan, it's still impressive but would be much more so if it was doubling max lifespan.

edit: Checked the data, interestingly there's a fairly wide range of death in the non-buckyball population (more than 1 year) but the buckyball population all died within 3 months, oddly enough none of the groups overlap, the data looks almost perfect. Will be interesting to see what the results are with more subjects.

Full Study: http://extremelongevity.net/wp-content/uploads/C60-Fullerene...

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#16

Post by fleitz »

carbocation wrote: post #8

Article: http://extremelongevity.net/wp-content/uploads/C60-Fullerene... The part getting the attention has to do with longevity; for that part of the article, data comes from "[t]hree groups of 6 rats". This was a single experiment in which n=6 rats received the C60 ('buckyball') composition, n=6 received just the oil, and n=6 received water (which can cause adverse effects in rats). Interestingly, a protective effe…

Could be that it's a fluke given the small groups involved.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#17

Post by Lost_BiomedE »

Be careful when looking at lifespan studies. A huge increase in lifespan vs. control does not mean much if the control is badly treated and short-lived compared to max lifespan for that rat strain. Some rats normally live to 42 months. The C60 could be making up for bad conditions without extending max lifespan. If so, many compounds have been shown to do this. This exact scenario was the cause of the resveratrol craze.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#18

Post by gus_massa »

fleitz wrote: post #15

This doubles median lifespan, not absolute lifespan, it's still impressive but would be much more so if it was doubling max lifespan. edit: Checked the data, interestingly there's a fairly wide range of death in the non-buckyball population (more than 1 year) but the buckyball population all died within 3 months, oddly enough none of the groups overlap, the data looks almost perfect. Will be interesting to see what t…

The median is more robust than the average, and the average that is more robust than the maximal or minimal.

* One strange case/rat can modify the maximal or minimal a lot (For example, some kill a rat with a gun or you are "lucky" and get a Methuselah rat.)

* A strange event also can modify the average a lot (If someone kill a rat immediately at the beginning of the experiment, the "new" average is approximately (n-1)/n times the "original" average.

* But some unusual problem doesn't modify the median too much. The median changes from the value of a rat to the value of the next/former rat, which is usually very close. But it doesn't matter how small or big the strange case is, the median is essentially fixed between two values, so it is difficult to modify too much.

The real problem is that 6 is a small number and it is difficult to get good statistical result with only 6 cases.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#19

Post by reasonattlm »

EvilTerran wrote: post #7

I find myself a little sceptical of articles on a website called "extreme longevity", to be honest... ... also, skimming the linked paper, the largest sample I see is "sixty rats randomly divided into 10 groups of 6 rats". I'm not sure if that's really large enough to draw any solid conclusions, and I don't see any P-values for the lifespan data -- but I freely admit I'm neither any kind of biologist nor a stats expe…

Actually, that's one of the few reputable casual sites that cover the field of aging and longevity research, along with my own, Fight Aging!

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#20

Post by Produce »

signa11 wrote: post #6
hesdeadjim wrote: post #4

Earlier quoted context omitted.

They had a plain olive oil control that increased the lifespan from 22 to 26 months, compared to 42 with the C60 + oil.

but, it also sez the following : "They also demonstrated that the compound is fully absorbed via the GI tract and totally eliminated from the body in 10 hours." so, not sure what causes the increase in life-span. although, the cryptic "attenuation of age-associated increases in oxidative stress" does hint at something , probably the effect that this combo causes as it is moving through the GI tract ?

"qwe sdawrqre sdzaamik3432 mkl" -> that's cryptic.

This is not, it's simply a bit vague. If it attenuates age-associated increases in oxidative stress then it probably has an anti-oxidant effect. Alternatively, it affects the systems responsible age-related oxidation - in other words, an indirect anti-oxidant action.

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