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FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

investor.lilly.com

11–20 of 95 posts

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#11
post #3

I see that it's another GLP-1 agonist, like Ozempic/Wegovy. Are there any particular advantages, or is it just a me-too drug?

It's a GIP agonist as well.

The weight loss number surpass that of semaglutide alone. https://www.nejm.org/doi/full/10.1056/nejmoa2107519

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#12
This is definitely a historic moment in US public health. Today we look at photos and marvel at how prevalent smoking was 50 years ago (in restaurants, in hospitals, in airplanes, etc.). 40 years from now people will look at photos from the last decade and be in disbelief at how widespread obesity was.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#13

Can't wait for the day semaglutide and tirzepatide are available as generics

From what I understand, Semaglutide is available in compounded form by pharmacies due to a shortage (without end in sight) being declared.

https://www.fda.gov/media/173456/download?attachment

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#14

This appears to be a GIP and GLP-1 agonist. Recently I read there might be some severe side effects with this class of med in diabetic and non-diabetic patients: https://medicalxpress.com/news/2023-10-links-popular-weight-... But its still pretty exciting.

AIUI, filtered through my doctor: the gastroparesis occurs when you stop eating. You stop eating because you're no longer hungry.

Remember to eat, and you don't get gastroparesis.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#16
post #12

This is definitely a historic moment in US public health. Today we look at photos and marvel at how prevalent smoking was 50 years ago (in restaurants, in hospitals, in airplanes, etc.). 40 years from now people will look at photos from the last decade and be in disbelief at how widespread obesity was.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#18
post #14

This appears to be a GIP and GLP-1 agonist. Recently I read there might be some severe side effects with this class of med in diabetic and non-diabetic patients: https://medicalxpress.com/news/2023-10-links-popular-weight-... But its still pretty exciting.

AIUI, filtered through my doctor: the gastroparesis occurs when you stop eating. You stop eating because you're no longer hungry. Remember to eat, and you don't get gastroparesis.

You don't have to eat anything particularly "hearty" / filling, though. Popcorn would do. Or cucumber. Just a bit of mass to keep things going.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#19
post #12

This is definitely a historic moment in US public health. Today we look at photos and marvel at how prevalent smoking was 50 years ago (in restaurants, in hospitals, in airplanes, etc.). 40 years from now people will look at photos from the last decade and be in disbelief at how widespread obesity was.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

What are the side effects? There's never a free lunch with biological systems...

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#20
post #13

Can't wait for the day semaglutide and tirzepatide are available as generics

From what I understand, Semaglutide is available in compounded form by pharmacies due to a shortage (without end in sight) being declared. https://www.fda.gov/media/173456/download?attachment

> Semaglutide is available in compounded form by pharmacies due to a shortage (without end in sight) being declared.

There's much less oversight over the production of compounded drugs, and people who purchase them may not be getting what they expect, with no way to tell the difference.

https://www.fda.gov/drugs/postmarket-drug-safety-information...

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