Also discussed at https://news.ycombinator.com/item?id=36982813
Oral cancer drug kills 100% of tumors in vitro and in animal models
11–20 of 108 posts
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#12https://en.m.wikipedia.org/wiki/AOH1996
Look at that molecular structure. Incredible.
Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight.
You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under ambient conditions.
I wouldn't be surprised if we soon see desperate, sick, rich people try this out on themselves, skipping FDA approval.
Beautiful, uplifting news. Let's hope the clinical trials proceed without issue.
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#13What’s the process for this to be tested and moved onwards toward approved use?
Tbh Since it's a small molecule you can just hire a lab to make a custom synth , I've seen it done a few times,
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#14Amazing if true, and can't be released soon enough. In the US this will likely be a million dollars or something insane, because its the US.
Or, people will set up home labs. Seems like it's not a complex molecule (but I have no real background).
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#15Absolute clickbait fraudulent title.
From the article in Cell:
"Given orally, AOH1996 suppresses tumor growth but causes no discernable side effect" is a VERY different result.
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#16Temper expectations, in vitro tests are very different than in vivo tests.
Arsenic also kills 100% of tumors in vitro.
In vitro doesn't answers the question of "can this drug be taken safely" nor "can this drug be delivered to the cancer cells"
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#17Amazing if true, and can't be released soon enough. In the US this will likely be a million dollars or something insane, because its the US.
The molecular compound is about as tricky to synthesize as viagra (which is to say, very simple as far as drug syntheses go), maybe even easier.
All it might take is some instagram cancer influencers, a lab in india or china and some darkweb transactions to DIY your cancer away... if this is so incredibly effective and safe in humans, too.
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#18Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#19Temper expectations, in vitro tests are very different than in vivo tests. Arsenic also kills 100% of tumors in vitro. In vitro doesn't answers the question of "can this drug be taken safely" nor "can this drug be delivered to the cancer cells"
Obligatory xkcd https://xkcd.com/1217/
Re: Oral cancer drug kills 100% of tumors in vitro and in animal models
#20Question from a layman: >100% of solid tumors Solid tumors == all cancer, or would something like a lymph node cancer not be included?
leukemia