Researchers treat depression by reversing brain signals traveling the wrong way

Post by wizzwizz4 » Wed, May 17, 2023, 3:38 PM UTC

radicaldreamer wrote: post #9

JohnMakin wrote: post #6

Unfortunately, TMS is extremely expensive and not likely to be covered by most insurance plans. Even with a decent PPO, I was quoted about $1k a treatment and they said I needed at minimum 30 treatments.

There are effective alternatives which are a fraction of the cost: ketamine (sublingual ~100mg every few days), psilocybin (free? cheap 2-3g ~4 weeks), rapamycin + ketamine also seems promising ( https://www.nature.com/articles/s41386-020-0644-9 ).

Post by comrh » Wed, May 17, 2023, 3:40 PM UTC

asdfman123 wrote: post #5

> “It’s almost as if you’d already decided how you were going to feel, and then everything you were sensing was filtered through that,” he said. “The mood has become primary.” This is 1000% what depression feels like, once you've properly come to terms with it. Your brain seems absolutely compelled to apply the most horrific, negative interpretation to everything that happens to you. Even when you understand it's wro…

Post by leksak » Wed, May 17, 2023, 3:42 PM UTC

asdfman123 wrote: post #8

e79 wrote: post #3

It’s fascinating how many potential modalities are at play with depression. Serotonin, inflammation, direction of brain signals. This suggests that depression may be a label that points to one of many underlying conditions, which could also explain why it’s so tricky to treat for some individuals.

As someone who has more or less successfully learned to deal with depression, ADHD, anxiety, etc., the trick is basically doing everything considered "healthy." We don't understand all of the mechanisms of long-term illnesses like depression, diabetes, heart disease, Alzheimer's, etc. but we do know how to fight them: exercise and good diet. * Some processes in the human body obviously get disrupted under modern cond…

Post by asdfman123 » Wed, May 17, 2023, 3:44 PM UTC

leksak wrote: post #15

asdfman123 wrote: post #8

Earlier quoted context omitted.

As someone who has more or less successfully learned to deal with depression, ADHD, anxiety, etc., the trick is basically doing everything considered "healthy." We don't understand all of the mechanisms of long-term illnesses like depression, diabetes, heart disease, Alzheimer's, etc. but we do know how to fight them: exercise and good diet. * Some processes in the human body obviously get disrupted under modern cond…

> But I also believe that if you don't exercise, eat nutritious food, get sunlight, get enough sleep, consume positive material, surround yourself with support, then you aren't giving yourself a fighting chance.” - Jim Carrey Sometimes though, any one of those or all of them can end up seeming impossible because of the depression one is fighting.

Post by tomrod » Wed, May 17, 2023, 3:48 PM UTC

JohnMakin wrote: post #6

Unfortunately, TMS is extremely expensive and not likely to be covered by most insurance plans. Even with a decent PPO, I was quoted about $1k a treatment and they said I needed at minimum 30 treatments.