I don’t get why any user has the ability to cause so much damage. Sure they can lock their own files out and need to restore from backup, but how can that knock out other departments, let alone things like email.
But that’s not how it’s done on these large enterprise networks. Ransomware gangs will still use single user entry points, but the hackers will work quietly inside the network to escalate privileges and determine key servers that should be targeted first.