This is an interesting article with regards to helping the V8 compiler optimise JavaScript code. Often, if C like speed is required, it would be easier to just write C rather than try emulate it through esoteric language features, but I wonder if these kind of compiler optimisations could be included via a language that compiles to JavaScript, such as CoffeeScript, at the expense of readability.
It's next to impossible to emit such code from language that is not statically typed.
Also it's not necessarily going to be faster than handwritten "human" JavaScript. There are a lot of factors in play. That's exactly what I am trying to stress in the blog post.