At least someone talks about more or less natural regeneration, not inventing more crutches (like mechanical organs or nanorobots).
Reversing hearing loss with regenerative therapy
11–20 of 215 posts
Re: Reversing hearing loss with regenerative therapy
#12Disclosure: I own FREQ stock. The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement. Animal research has shown that natural cochlear hair cell regeneration and re…
“Animal research has shown that natural cochlear hair cell regeneration and resultant hearing restoration is very real” - Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is some cool tech, but just wanted to point it out that success in animal models =/= we will eventually get to see the realized treatment.
Re: Reversing hearing loss with regenerative therapy
#13Disclosure: I own FREQ stock. The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement. Animal research has shown that natural cochlear hair cell regeneration and re…
Looks like FREQ stock got really beat down over the last few months- any idea what happened was it the negative outcome of the study you mentioned?
There was suspected fraud on the part of the C(E?)O that he was soliciting investor money (and sold stock himself) with advance knowledge of the disappointing results of the trial I was mentioning and did not disclose it. Class action suits were filed.
The trials preceding the Phase IIa results were all extremely promising, and even the Phase IIa one showed statistically significant effect on a sound discrimination, which many long time hearing sufferers can tell you is even more frustrating a problem than the inability to perceive sound.
Biomedical research stocks are inherently risky. I could be deluding myself, but my lay reading of the research, and as someone who has suffered from tinnitus for a long time brought on my noise overexposure, I think there is a very promising shot at this drug. Maybe FREQ will not be the ones to realize it and some other company will take the patent into real life clinical medicine, and FREQ is certainly not the ONLY company pursuing this angle. But their successes so far have kept me holding the stock, and I keep buying more.
Re: Reversing hearing loss with regenerative therapy
#14Any patients that reported their Tinnitus getting better? It has been a real curse having chronic tinnitus.
Re: Reversing hearing loss with regenerative therapy
#15Related work at Johns Hopkins [2019]:
Re: Reversing hearing loss with regenerative therapy
#16For anybody suffering with tinnitus I highly recommend the protocol William Shatner went through. You can train your brain so it’s not noticeable any more. Like wearing pants, it fades into the background.
Re: Reversing hearing loss with regenerative therapy
#17For anybody suffering with tinnitus I highly recommend the protocol William Shatner went through. You can train your brain so it’s not noticeable any more. Like wearing pants, it fades into the background.
Thanks for the recommendation, will look it up. I have friends who suffer from tinnitus and I hope it can help them.
Re: Reversing hearing loss with regenerative therapy
#18Disclosure: I own FREQ stock. The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement. Animal research has shown that natural cochlear hair cell regeneration and re…
Why would they deliberately come up with a study design that harms their evaluation, trust, reputation, etc. and not one that optimized for best lab-condition results, like any sensible hair loss product company, for example?
Re: Reversing hearing loss with regenerative therapy
#19Disclosure: I own FREQ stock. The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement. Animal research has shown that natural cochlear hair cell regeneration and re…
Do you have more links, which make you have confidence in FX-322 and related treatments ?
Re: Reversing hearing loss with regenerative therapy
#20>drug candidate stimulates the growth of hair cells in the inner ear.
Oh I don't have trouble growing hair in my ears. I have trouble hearing.