Protein tweak makes CRISPR gene editing 4k times less error-prone

Post by pdevr » Fri, Mar 04, 2022, 4:56 PM UTC

axg11 wrote: post #10

pdevr wrote: post #4

I may be way out of my depth, but until we can edit all the cells of a living organism, isn't CRISPR limited to working with pre-embryos/embryos? If so, other than creating a potential super race, what is it of benefit to the living individuals with "imperfect" genes? Just to clarify, that is a real question, not rhetoric.

(Context: I have a PhD in genomics - but not necessarily an expert in this sub-field) It is possible, but still difficult, to edit cells in-place. One example is the liver, a highly vascularized tissue (lots of blood vessels). This means that you can use a blood-based delivery method, e.g. blood infusion of CRISPR components + other compounds that allow these components to enter cells. Over time, more of the liver ce…

Post by ritwikr » Sun, Mar 13, 2022, 3:49 AM UTC

BizarroLand wrote: post #12

furstenheim wrote: post #6

Earlier quoted context omitted.

They applied crispr to bone marrow. Extract it, apply crispr. Cleanse the body to remove existing one and apply modified barrow. Basically an auto transplant with marrow

I wonder if that can be used as a treatment in conjunction with finding the gene that gives some people immunity to HIV