It takes time above all. Time to get legal issues sorted out. To have the administration and legislation sorted out properly. To have your insurances set up. To have proper help and support in place. And to have your entire venture -including the software- thourougly benchmarked and security-tested.
The BTC-economy is very young. Most of the ventures you see there now, never set up a proper and professional venture; one that can deal with multimillion of dollars. They are of the order of a few quickly hacked up scripts. Perfect for selling a few socks per week. But not for value-storage worth millions.
We must be patient: the ventures who have stuff properly in place will appear, but later; after they have everything in place and secured to really run such ventures.