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Melatonin may decrease risk for and aid treatment of Covid-19

openheart.bmj.com

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Re: Melatonin may decrease risk for and aid treatment of Covid-19

#11

Post by TrevorJ »

denysonique wrote: post #4

What if it is not melatonin itself, but the fact that it helps to get more sleep which generally boosts the immune system and has anti-inflamatory effects. Sleep length/quality should have been taken into account. Have scientists rediscovered the importance of sleep?

This is, of course, the right question to ask. The good thing is, we can still reasonably act on this data while we wait for more studies to disentangle the cause/correlation relationship. Melatonin is well tolerated, and also produced endogenously, so the risk/reward on this treatment is in our favor.

Re: Melatonin may decrease risk for and aid treatment of Covid-19

#12

Post by Andys »

Something1234 wrote: post #5
Andys wrote: post #2

After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.

Can you provide proof of this or links to research? Making claims like this is counter productive and only helps to empower the antivaxxers.

Sorry about that. It isn't really anything to do with the vaccines. It is simply something that may help others, since some unfortunate few (very small %) are even getting "long covid" from just the vaccine alone.

Niacin appears to be very well studied, but not in the context of post-viral illnesses. But there are a mountain of papers which may help to explain why it works. Here are a few:

Underlying lack of niacin and establish indicated use: https://academic.oup.com/bib/article/22/2/1279/5964187 https://clinmedjournals.org/articles/jide/journal-of-infecti...

Lipids in covid: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869689/ Sars CoV 2 entry to cells: https://www.nature.com/articles/s42255-020-00324-0 Replication etc: https://journals.plos.org/plospathogens/article?id=10.1371/j... Nicotinic acid’s effects on lipids: https://www.eurekaselect.com/126340/article

Re: Melatonin may decrease risk for and aid treatment of Covid-19

#13

Post by Andys »

dhirenb wrote: post #9
Andys wrote: post #2

After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.

Can you give some information or links to what was the dosage and frequency?

Up to 1000mg once per day now, but had to work up slowly over a couple of months, as I wasn't able to tolerate even 10mg at first. You need the "flushing" type of nicotinic acid (it causes your skin to go hot and red for about half an hour, but tolerance of this gradually increases), avoid the "slow release" or "non-flushing" forms of Nicotinic acid. For melatonin I started on 3mg and worked up to 9mg.

Re: Melatonin may decrease risk for and aid treatment of Covid-19

#14

Post by nikolay »

denysonique wrote: post #4

What if it is not melatonin itself, but the fact that it helps to get more sleep which generally boosts the immune system and has anti-inflamatory effects. Sleep length/quality should have been taken into account. Have scientists rediscovered the importance of sleep?

And that's not what melatonin does.

Re: Melatonin may decrease risk for and aid treatment of Covid-19

#15

Post by mousepilot »

Andys wrote: post #12
Something1234 wrote: post #5

Earlier quoted context omitted.

Can you provide proof of this or links to research? Making claims like this is counter productive and only helps to empower the antivaxxers.

Sorry about that. It isn't really anything to do with the vaccines. It is simply something that may help others, since some unfortunate few (very small %) are even getting "long covid" from just the vaccine alone. Niacin appears to be very well studied, but not in the context of post-viral illnesses. But there are a mountain of papers which may help to explain why it works. Here are a few: Underlying lack of niacin a…

Whats the mechanism for long covid from vaccines? Didn't think any of the links mentioned that.

Re: Melatonin may decrease risk for and aid treatment of Covid-19

#16

Post by Andys »

mousepilot wrote: post #15
Andys wrote: post #12

Earlier quoted context omitted.

Sorry about that. It isn't really anything to do with the vaccines. It is simply something that may help others, since some unfortunate few (very small %) are even getting "long covid" from just the vaccine alone. Niacin appears to be very well studied, but not in the context of post-viral illnesses. But there are a mountain of papers which may help to explain why it works. Here are a few: Underlying lack of niacin a…

Whats the mechanism for long covid from vaccines? Didn't think any of the links mentioned that.

No idea - I haven't even seen it officially recognized, or studied. But I can guess its all to do with the spike protein.
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