I've love to hear what this means for realtime multi-channel audio applications. Would someone close to this give us a summary, or recommend some resources for the only-barely-knowledgeable?
This does mean that some older gear which requires bespoke drivers and is no longer maintained will never work with new MacOS - one example that comes to mind is Allen and Heath’s Xone DB2 DJ mixer. Quite a lot of newer gear is USB class compliant, which means it doesn’t need specific drivers and so should be future proof.