Live data from Hacker News

Pfizer and Moderna vaccines may produce lasting immunity

nature.com

11–20 of 364 posts

Re: Pfizer and Moderna vaccines may produce lasting immunity

#12
post #7

The mRNA vaccines have been the silver lining to the whole COVID-19 disaster. They seem “unreasonably effective” against COVID, basically if you had a genie that you could ask to make a vaccine, it would be hard to do much better, other than the requirement for 2 jabs. In addition, the mRNA technology has broad applicability to other issues such as other viruses (such as flu) and even cancer!

Do we have any proof that the second dose is useful at all ?

There's very strong evidence, particularly against the Delta variant[1]. That paper cites a 33.5% effectiveness after one dose, compared to 87.9% after two doses of the Pfizer/BioNTech vaccine.

[1]: https://www.medrxiv.org/content/10.1101/2021.05.22.21257658v...

Re: Pfizer and Moderna vaccines may produce lasting immunity

#14

Earlier quoted context omitted.

We'll "need" to take periodic boosters to improve Moderna and Pfizer's profit margins. That said, given its safe, I'm happy to do it to help fund / drive investment into the mRNA supply chain.

I would caution you to reconsider "given it's safe" as a statement. I think the proper statement might be closer to "the benefits can outweigh the risks, depending on the disease being treated". There are growing bodies of evidence that spike proteins travel throughout your body, don't stay isolated at the injection site, and can cause severe reactions in some people (see incidents of heart inflammation, etc). I was…

> There are growing bodies of evidence that spike proteins travel throughout your body, don't stay isolated at the injection site, and can cause severe reactions in some people

Will you share citation(s) for the evidence you mention?

I'm aware of the heart inflammation concerns, but as of yet, I have not seen this described as "the spike protein traveling throughout your body".

> In other words, for "minor" illnesses like flu, it might not be a net benefit.

The spike proteins exist only to provide immunity to this specific coronavirus. What are you suggesting re: illnesses like flu?

Re: Pfizer and Moderna vaccines may produce lasting immunity

#15
post #8
post #4

This is great news, adding to a report in Nature that the natural immunity produced in people who have already had covid may last a lifetime.[1] In case you hadn't heard, the Cleveland Clinic--consistently regarded as one of the top hospital systems in the United States and in the world--recently shared a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected, recommending t…

It's time for the naturally immune to be treated the same as those who've been vaccinated. There is absolutely zero scientific evidence to the contrary, and plenty of evidence to support it.

It’s hard to reliably verify previous infection and very safe and easy to get vaccinated, so what’s the point?

I’m going to check your profile — 90% chance you spread antivax propaganda.

Edit: yup. Every time.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#16
post #4

This is great news, adding to a report in Nature that the natural immunity produced in people who have already had covid may last a lifetime.[1] In case you hadn't heard, the Cleveland Clinic--consistently regarded as one of the top hospital systems in the United States and in the world--recently shared a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected, recommending t…

The headline for the second article is with regards to prioritizing vaccination in places where demand outstrips supply. The conclusion of the study is:

"Individuals who have had SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination, and vaccines can be safely prioritized to those who have not been infected before."

And from the body of the article:

"Experts say that more research is needed to determine how long immunity lasts after a case of COVID-19. Until we have that data, some infectious disease specialists are recommending that people who’ve had COVID-19 still get one dose."

And:

"Given the limited availability of the vaccines in certain countries, the findings add to the growing belief that the vaccines should be prioritized for those who haven’t previously had COVID-19."

Re: Pfizer and Moderna vaccines may produce lasting immunity

#18

Earlier quoted context omitted.

We'll "need" to take periodic boosters to improve Moderna and Pfizer's profit margins. That said, given its safe, I'm happy to do it to help fund / drive investment into the mRNA supply chain.

I would caution you to reconsider "given it's safe" as a statement. I think the proper statement might be closer to "the benefits can outweigh the risks, depending on the disease being treated". There are growing bodies of evidence that spike proteins travel throughout your body, don't stay isolated at the injection site, and can cause severe reactions in some people (see incidents of heart inflammation, etc). I was…

For a lot of people, influenza is deadly, and so not at all "minor". Outside of pandemic, we should move slowly and cautiously, but yeah, if we can perfect this out to a better way to fight the flu, that'd save a lot of lives.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#20
post #8
post #4

This is great news, adding to a report in Nature that the natural immunity produced in people who have already had covid may last a lifetime.[1] In case you hadn't heard, the Cleveland Clinic--consistently regarded as one of the top hospital systems in the United States and in the world--recently shared a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected, recommending t…

It's time for the naturally immune to be treated the same as those who've been vaccinated. There is absolutely zero scientific evidence to the contrary, and plenty of evidence to support it.

If someone opposes that common sense, I’d have to wonder what their agenda is tbh.
Post reply on HN