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Pfizer vaccine reprograms innate immune responses

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11–20 of 75 posts

Re: Pfizer vaccine reprograms innate immune responses

#11
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

For me I'm waiting $N years till I consider getting a covid shot.

According to the oxford calculator[0] my risk of hospitalization is microscopic so I take that chance over trying out new under-tested vaxines.

[0] https://qcovid.org/

Re: Pfizer vaccine reprograms innate immune responses

#12
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

As far as I can tell the difference between the pfizer and moderna vaccines are negligible. The results of differences in their testing procedure and conditions - the stuff you’re getting is basically the same. So, unless you’re (in my opinion) wrongly calculating the risk from a vaccine as larger than the risk from the disease, the best shot is the one you can get soonest.

Re: Pfizer vaccine reprograms innate immune responses

#13
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

For me I'm waiting $N years till I consider getting a covid shot. According to the oxford calculator[0] my risk of hospitalization is microscopic so I take that chance over trying out new under-tested vaxines. [0] https://qcovid.org/

I for one value keeping my sense of smell and taste higher than the risks i’m seeing from vaccines - eliminating the risk of hospitalization is just a bonus

Re: Pfizer vaccine reprograms innate immune responses

#14
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

For me I'm waiting $N years till I consider getting a covid shot. According to the oxford calculator[0] my risk of hospitalization is microscopic so I take that chance over trying out new under-tested vaxines. [0] https://qcovid.org/

My fiance and I are holding out for same reasons.

Re: Pfizer vaccine reprograms innate immune responses

#15

Earlier quoted context omitted.

For me I'm waiting $N years till I consider getting a covid shot. According to the oxford calculator[0] my risk of hospitalization is microscopic so I take that chance over trying out new under-tested vaxines. [0] https://qcovid.org/

I for one value keeping my sense of smell and taste higher than the risks i’m seeing from vaccines - eliminating the risk of hospitalization is just a bonus

I don't agree on waiting years for a vaccine, however the loss/alteration of sense of smell and taste is temporary. It can last more than the other symptoms, but usually after a few weeks it gets back to normal again.

I got symptomatic Covid last October and the spike protein test taken at the end of March reports I still have several hundreds u/ml of anti-rbd antibodies, so I'll be reasonably safe for some time, but wouldn't recommend waiting to not immunized people. I had people dying next to my bed, and that is something I can't unsee for the rest of my life.

Re: Pfizer vaccine reprograms innate immune responses

#16
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

On the contrary, I was excited to finally get it yesterday, even though I already had immunity.

Re: Pfizer vaccine reprograms innate immune responses

#17
post #6

Not peer reviewed

Not that that would help anyway. That's becoming increasingly an appeal to authority. There isn't anybody to do the review that isn't a colleague or a competitor, or worse part of an established GroupThink.

Peer review has had its day due to specialisation in science. The gold standard now has to be replication from the published method.

Therefore: not replicated.

Re: Pfizer vaccine reprograms innate immune responses

#18
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

Johnson and Johnson. Because you only need one shot and you are good to go. Immediately followed by whatever vaccine is available at the moment. Which leaves, at least for the next couple of weeks, with option three: none of the above.

So definitely not holding out.

Re: Pfizer vaccine reprograms innate immune responses

#19
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

For me I'm waiting $N years till I consider getting a covid shot. According to the oxford calculator[0] my risk of hospitalization is microscopic so I take that chance over trying out new under-tested vaxines. [0] https://qcovid.org/

I hope you continue to social distance for $N years, because vaccination isn't just about you -- its about protecting those who would be at risk.

It's also about reducing the risk of mutation. The more people it can infect, the greater the risk. We don't want to be dealing with a new variant that the vaccines don't protect against, and go back to square one.

Being scared of a well-tested vaccine over a virus that has killed 3.5 million worldwide and continues to do so is ridiculous. The vaccine is why things are slowly starting to return to normal.

Re: Pfizer vaccine reprograms innate immune responses

#20
post #3

I'm honestly pretty torn at this point which vaccine I should be going for. It seems like every week there is another article insinuating that there is some poorly understood, potentially high impact, facet of a given vaccine. Anyone else "holding out?"

As far as I can tell the difference between the pfizer and moderna vaccines are negligible. The results of differences in their testing procedure and conditions - the stuff you’re getting is basically the same. So, unless you’re (in my opinion) wrongly calculating the risk from a vaccine as larger than the risk from the disease, the best shot is the one you can get soonest.

Given a choice, I would choose Pzifer over Moderna, since it has fewer side effects [1], but otherwise they're both good and protect approximately equally against known variants. I wouldn't choose J&J or AZ if my age is below 60yo because of a very low risk of deadly side effects (clots).

Edit: unless my BMI > 30, in which case any vaccine is better than no vaccine, because of the increased risks of covid-19 on high BMI.

[1] https://www.europeanreview.org/article/24877

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