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Psilocybin 'promising' for depression

bbc.co.uk

11–20 of 324 posts

Re: Psilocybin 'promising' for depression

#13

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

It will be looked back upon the same as alcohol prohibition.

Re: Psilocybin 'promising' for depression

#14

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

It will be looked back upon the same as alcohol prohibition.

Meaning the prohibition was misguided but the drug itself is dangerous?

Re: Psilocybin 'promising' for depression

#15
The study was just published in the most prestigious medical journal in the world [1].

Whatever you think of the study, this is rather significant. If you told me even 2 years ago there would be a randomised trial of magic mushrooms in NEJM, I would not have believed it for even a second.

One point not to miss is that they screened 1000 patients to come up with the study population of 59.

Nevertheless, I consider the study result quite promising, considering patients only had 2 doses of psilocybin.

[1] https://www.nejm.org/doi/full/10.1056/NEJMoa2032994

Re: Psilocybin 'promising' for depression

#16

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

This is my experience too. I’ve been microdosing about 1.3mg on and off during lockdown. The effects are subtle and hard to describe but I’d say it’s like ‘opening your mind’ or reframing your point of view on things. Definitely different from other drugs which just pump you with serotonin

Re: Psilocybin 'promising' for depression

#17

I’m going to cluster HN news stories by topic and then write a script to filter the same content out.

French call this kind of repetitive, easy to write and not worth reading articles "marronniers" (literally "chestnut tree"), supposedly because some famous tree was worth an annual subject. In case you need to name your project :)

On the other hand, I would prefer to filter out the comments marronniers. You know, the mushroom anecdotes, the quality of the Mac trackpad, ...

Re: Psilocybin 'promising' for depression

#18

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.

This is why research is needed. My gut feeling is that the root cause is overdosing. Just search "How often can I do shrooms" on Quora and you get the gamut from "1 or 2 times per year", to "microdosing everyday, macrodose every weekend, and hero dose every month".

Re: Psilocybin 'promising' for depression

#19

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.

Why is this being downvoted? Studies are great, but let's not act like drugs are suddenly safe to use in all cases. I'm sure the studies didn't conclude that.

Be pro-shrooms but don't act like they're safe in every case. Education is required before partaking in anything, let alone shrooms.

Re: Psilocybin 'promising' for depression

#20
post #15

The study was just published in the most prestigious medical journal in the world [1]. Whatever you think of the study, this is rather significant. If you told me even 2 years ago there would be a randomised trial of magic mushrooms in NEJM, I would not have believed it for even a second. One point not to miss is that they screened 1000 patients to come up with the study population of 59. Nevertheless, I consider the…

"If you told me even 2 years ago there would be a randomised trial of magic mushrooms in NEJM, I would not have believed it for even a second."

In a lot of ways, that's completely depressing for how slowly we've come as a species.

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