11–20 of 389 posts
Earlier quoted context omitted.
We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact But for now we can inject code to trigger protein configuration via the immune system
Does that mean a cytokine storm is the equivalent of a buffer overflow or a DoS?
Earlier quoted context omitted.
We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact But for now we can inject code to trigger protein configuration via the immune system
Does that mean a cytokine storm is the equivalent of a buffer overflow or a DoS?
https://gizmodo.com/stanford-scientists-post-entire-mrna-seq...
What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
It's the 3' (3-prime) UTR (un-translated region). It can affect the translation of the mRNA. https://en.wikipedia.org/wiki/Three_prime_untranslated_regio... . The next thing is the poly-A tail: https://en.wikipedia.org/wiki/Polyadenylation blasting the 3' UTR, we see it ~50% of it was copied from the human mitochondria tldr, extra regulatory signals (often not well understood)
What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
What they actually do can vary, but essentially they can provide places for other things to bind and influence what happens with the mRNA. There are some fancier cases like riboswitches, but you don't see those in humans. The stuff at the start and end of the mRNA also determines stability of the mRNA.
'A group of Stanford researchers has hacked Moderna’s messenger RNA (mRNA) vaccine for the novel coronavirus, Motherboard first reported on Monday, and published its entire genetic sequence on the open-source code repository Github.' https://gizmodo.com/stanford-scientists-post-entire-mrna-seq...
> Fire and Shoura told Motherboard that they had received permission from the FDA to collect scraps of vaccines that wouldn’t have otherwise been used from empty vials and that they’d notified Moderna in advance of their plans to publish the sequence without receiving any objection in turn.
Also:
> The research team told Motherboard that they didn’t “reverse engineer” the vaccine, they simply “posted the putative sequence of two synthetic RNA molecules that have become sufficiently prevalent in the general environment of medicine and human biology in 2021.”
I'm not familiar enough with how these sequences to work to understand what's being discussed. Is it simply that they took a sample of the vaccine and studied its composition using some standard machine/process?
What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
The Moderna one has the 3'-UTR of the alpha subunit of human hemoglobin.
What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
It's the 3' (3-prime) UTR (un-translated region). It can affect the translation of the mRNA. https://en.wikipedia.org/wiki/Three_prime_untranslated_regio... . The next thing is the poly-A tail: https://en.wikipedia.org/wiki/Polyadenylation blasting the 3' UTR, we see it ~50% of it was copied from the human mitochondria tldr, extra regulatory signals (often not well understood)