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EU agency says AstraZeneca vaccine is 'safe and effective'

bbc.co.uk

11–20 of 41 posts

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#11
Surely it's inevitable that during a worldwide rollout of a new vaccine a few 'pauses' happen -- even if people find them deeply distressing. Lots of people were claiming this was politically motiviated reather than scientificially motivated.

Does this confirm the motivations were scientific?

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#12
post #7

For those that want a bit of evidence and scientific background on this, Derek Lowe's writings are, as usual, an excellent source. https://blogs.sciencemag.org/pipeline/archives/2021/03/16/wh... It is a scientifically and statistically rigorous look at the available data that takes into account how people probably feel about the whole issue.

I think this article is a bit more nuanced based on what they are seeing on the ground. Derek brings up good points about background rates, but papers over some things. It's a complex picture and the below article paints it well.

Also scientists in Norway claim they found the mechanism that causes it.

https://www.sciencemag.org/news/2021/03/it-s-very-special-pi...

https://www.vg.no/nyheter/innenriks/i/KyGv2G/professor-says-...

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#13
I think the EMA press release is a better source: https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazene...

Specifically it doesn't say "safe and effective", it says "benefits outweight risks" (BBC says that at well, but they removed that bit from the headline).

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#14
post #9

Earlier quoted context omitted.

>but I pity the ones they go first and suffer from overzealous cheerleading of a particular vaccines efficacy Given the incident rate and the growing COVID swells in a few european countries (France and Italy especially), the slow vaccination progress, not helped by hesitance over AZ and surprising prevalence of vaccine hesitancy in general, you could just as well argue the opposite. Nations that are overcautious may…

> Nations that are overcautious may lose far, far, far, far more lives thanks to covid infections than an extremely rare handful of blood clots which haven't even been tied concretely to the vaccine yet. The risk reward analysis on this topic has been really bizarre so far. You seem to suggest risk-reward analysis be viewed at by the number of deaths. Germany had to suspend vaccination (temporarily) due to legal reas…

Actually talking about the risk reward analysis in the media and general commentary reaction to the AZ vaccine rather than by nations. Think it's perfectly reasonable for nations to conduct safety checks and research on new vaccines

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#15

At the moment this is right next to “ Norwegian experts say AstraZeneca vaccine is behind the deadly blood clots” on the front page. I think it’s up to each nation to decide for itself if a vaccine is going to work or not, but I pitty the ones they go first and suffer from overzealous cheerleading of a particular vaccines efficacy.

If it is up to each nation, that's too bad. We should be treating adults as adults, telling them "here's the information: about 30 people had bloodclots out of 5,000,000 having received the vaccine (source: https://www.bbc.com/news/uk-56397592). We're not sure if any of those 30 are linked to the vaccine. If those risks seem acceptable to you, here's the vaccine."

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#16
post #13

I think the EMA press release is a better source: https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazene... Specifically it doesn't say "safe and effective", it says "benefits outweight risks" (BBC says that at well, but they removed that bit from the headline).

I believe the title is from the EMA press conference, @ 07:20[1]

“ The committee has come to a clear scientific conclusion: This is a safe and effective vaccine. Its benefits in protecting people from COVID19 with the associated risks of death and hospitalization outweigh the possible risks.”

  [1] https://youtu.be/qYmP02SIQNI

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#17
post #7

For those that want a bit of evidence and scientific background on this, Derek Lowe's writings are, as usual, an excellent source. https://blogs.sciencemag.org/pipeline/archives/2021/03/16/wh... It is a scientifically and statistically rigorous look at the available data that takes into account how people probably feel about the whole issue.

I think this article is a bit more nuanced based on what they are seeing on the ground. Derek brings up good points about background rates, but papers over some things. It's a complex picture and the below article paints it well. Also scientists in Norway claim they found the mechanism that causes it. https://www.sciencemag.org/news/2021/03/it-s-very-special-pi... https://www.vg.no/nyheter/innenriks/i/KyGv2G/professo…

I was going to post the same link, as I also feel that this article is more nuanced.

There is also a twitter thread by one of the article's authors summarizing the article and discussing some additional information.

https://twitter.com/kakape/status/1372315648894844940

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#18
post #8

about 3/4 of theway thru the text i finally find some numbers >>What has AstraZeneca said? The company says there is no evidence of an increased risk of clotting due to the vaccine. It said it had received 37 reports of blood clots out of more than 17 million people vaccinated in the EU and UK as of 8 March. 37 reports out of 17 million vaccinations. this is aprox. 1 report out of 510 000 vaccinations. what is not sh…

According to some interviews and sources, the Sinus blood clots are more likely to happen with AZ. I haven't seen any numbers, especially accounting for age and demographic groups, so I cannot tell.

That being said, every drug has side effects. A vaccine isn't any different.

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#19
If they keep vaccinating with this vaccine and it does turn out that the vaccine causes the deadly blood clots it will destroy the legitimacy of vaccines. "they pushed the vaccine despite knowing that it kills some people" is how it will be framed. Even though I agree that for health reasons continuing to use it is almost certainly correct, not considering the public opinion is madness and will cause massive issues. Do not increase vaccine skepticism beyond where it's already at.

Re: EU agency says AstraZeneca vaccine is 'safe and effective'

#20

Earlier quoted context omitted.

>but I pity the ones they go first and suffer from overzealous cheerleading of a particular vaccines efficacy Given the incident rate and the growing COVID swells in a few european countries (France and Italy especially), the slow vaccination progress, not helped by hesitance over AZ and surprising prevalence of vaccine hesitancy in general, you could just as well argue the opposite. Nations that are overcautious may…

Right. The WHO listed 'vaccine hesitancy' as one of the top global health threats, and that was in mid 2019, before the pandemic. [0] On the other hand, vaccine side-effects have never been a major health threat. [0] https://en.wikipedia.org/wiki/Vaccine_hesitancy

I think this vaccine and vaccines in general are overwhelmingly safe, but has this not been a slightly different situation?

Admittedly, I don't know much about vaccine safety, but isn't it unusual to have a vaccine rolled out to millions of otherwise healthy people without any long-term studies into its safety? I understand we create new flu vaccines yearly, but my understanding is that's a slight variant of previous flu vaccines which have been proven to be safe over long periods of time – and it's only rolled out to vulnerable people who want it, not everyone under threat of not being able to travel, etc.

I think we probably should have some level of caution when taking any new drug or vaccine – especially one that is going to be rolled out to millions of people. How many times would we need to run this experiment before a 'safe' vaccine does actually cause blood clots or some similar side effect? Or are side effects from vaccines basically impossible? (I genuinely don't know).

For some context, I'm saying this as someone who now suffers from permanent side effects after taking a medication that was once deemed safe and without risk of permanent side effects so unfortunately its hard for me not to be a little hesitant.

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