Several months ago there was a post about vitamin D supposedly being effective in preventing hospitalization. What happened to that idea?
It's been confirmed and supported by other studies.
Early clinical trial shows anti-depressant prevents hospitalization from Covid
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Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#12To be clear, this isn't saying that any anti-depressant is effective for COVID. It appears to be a unique side-effect of Fluvoxamine. There are several existing drugs which have been found to have modulatory effects on early COVID infections. The key word here is "early", as most of them only have a significant impact before the infection gets out of control. Keep in mind that Hydroxychloroquine is one of the existin…
It would probably be any SSRI though?
It's suspected to be a specific side effect, not a part of the reuptake inhibition.
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#13Several months ago there was a post about vitamin D supposedly being effective in preventing hospitalization. What happened to that idea?
Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it.
https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict...
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#14To be clear, this isn't saying that any anti-depressant is effective for COVID. It appears to be a unique side-effect of Fluvoxamine. There are several existing drugs which have been found to have modulatory effects on early COVID infections. The key word here is "early", as most of them only have a significant impact before the infection gets out of control. Keep in mind that Hydroxychloroquine is one of the existin…
It would probably be any SSRI though?
Generally speaking, "SSRI" is an ideal goal which isn't perfectly realized; all drugs in that class bind "off-target" to proteins other than SERT.
In this case, fluvoxamine pharmacology is pretty clean and there is experimental evidence only for binding to sigma-1 receptor in addition to SERT (also to a whole bunch of CYP enzymes).
Unfortunately the function of sigma-1 is not well understood but it affects calcium signalling in intracellular compartments where covid-19 replicates
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#15Several months ago there was a post about vitamin D supposedly being effective in preventing hospitalization. What happened to that idea?
Yes, dosage should be 10k IU / day for starters with 5mg vitamin K2. Fat-soluble so take with a meal.
Vitamin D depletes Vitamin A and magnesium, get the former from foods and supplement the latter as magnesium glycinate and/or chloride.
Other common & relevant deficiencies are boron and zinc, especially zinc.
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#16Several months ago there was a post about vitamin D supposedly being effective in preventing hospitalization. What happened to that idea?
Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4
Yes, but are governments recommending it? Are doctors recommending it? Is WHO recommending it? I didn't hear anything about it except from that one post on HN, which I think is quite strange. If this works, then shouldn't there be a nation-wide plan to introduce more vitamin D in the diets of people?
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#17Earlier quoted context omitted.
Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4
Yes, but are governments recommending it? Are doctors recommending it? Is WHO recommending it? I didn't hear anything about it except from that one post on HN, which I think is quite strange. If this works, then shouldn't there be a nation-wide plan to introduce more vitamin D in the diets of people?
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Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#18Earlier quoted context omitted.
Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4
Yes, but are governments recommending it? Are doctors recommending it? Is WHO recommending it? I didn't hear anything about it except from that one post on HN, which I think is quite strange. If this works, then shouldn't there be a nation-wide plan to introduce more vitamin D in the diets of people?
Are you unconvinced? You know basically vitamin D is a kind of "master regulator" of metabolism / immune system.
Deficiency of vitamin D is immune system dysfunction.
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#19Several months ago there was a post about vitamin D supposedly being effective in preventing hospitalization. What happened to that idea?
Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4
It has shown to be correlated with better outcomes. It is also correlated with being healthier, being active, and eating better. As far as I understand there is no strong evidence for a causal relationship.
To be clear, if you live in the northern hemisphere, you should be taking vitamin D. It's cheap and at worst harmless. But that's not the same as saying it will improve the outcome of covid patients.
Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid
#20Earlier quoted context omitted.
Yes, but are governments recommending it? Are doctors recommending it? Is WHO recommending it? I didn't hear anything about it except from that one post on HN, which I think is quite strange. If this works, then shouldn't there be a nation-wide plan to introduce more vitamin D in the diets of people?
Are you unconvinced? You know basically vitamin D is a kind of "master regulator" of metabolism / immune system. Deficiency of vitamin D is immune system dysfunction.
I believe the studies, but my question is why do we let the health system suffer if there is such a simple solution? Why isn't "take vitamin D" in the same list as "wash your hands often" and "keep distance"?