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Biomarker of Alzheimer's found to be regulated by sleep cycles

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11–20 of 181 posts

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#11

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.

It's not a good book and was basically just used to get Matt Walker on daytime talk shows. It doesn't even attempt to answer the question in its title, and it has many cherry picked studies that don't actually prove what he's implying they do.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#14

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.

It's a great book for emphasizing the importance of sleep. The author's desired outcome is to get people interested in healthy sleep habits, and he hits a home run in that regard.

However, take some of the science positions in the book with a grain of salt. The author is notorious for being directionally correct in his opinions, but exaggerating a lot of the science for dramatic effect. This doesn't matter at all if you're reading the book to convince yourself to build better sleep habits, of course.

However, it does seem to leave some people with exaggerated worries or anxiety about dying early or developing serious disease conditions if they've ever gone through periods of life with short sleep (college, raising kids, video game addiction) or if they're in a life situation that limits their sleep. In that regard, it's worth noting that the author is really stretching some of the studies and cherry-picking results to support his argument. Getting 6 hours per sleep at night will not be the death of you, despite what the book suggests.

It's also commonly known that people get less sleep than they think they do. Someone might tell you they get 8 hours of sleep each night because they try to sleep from 11PM to 7AM, but in reality they stretch their bed time to midnight more often than not and then read their phone in bed for 15-30 minutes. Sleep advocates try to compensate by exaggerating target sleep times for adults to 8 hours. In reality, 7-ish hours of sleep appears to be just fine for most adults, with some requiring less and others requiring more. That said, most people will have to target 8 hours of dedicated bed time to really get those 7 hours of sleep in practice, hence the common exaggerations.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#15

Taking bets that caffeine consumption will be found to be a comorbidity.

Studies suggest it might be neutral or even protective in Alzheimer's: https://pubmed.ncbi.nlm.nih.gov/20182054/

> In the CAIDE study, coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life. In conclusion, coffee drinking may be associated with a decreased risk of dementia/AD. This may be mediated by caffeine and/or other mechanisms like antioxidant capacity and increased insulin sensitivity.

Not all studies are this positive. Note that sleep deprivation is still a risk factor, with or without the aid of caffeine.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#18

Taking bets that caffeine consumption will be found to be a comorbidity.

I sure hope not. I increased my caffeine consumption intentionally 5x in the past decade because alzheimer's runs in both sides of the family.

I'm not a doctor, just a person who also has Alzheimer's in his family, so I've thought and read a lot about it. My recipe is basically:

Sleep enough, exercise (especially outside), eat right, make sure your brain is active and engaged on a regular basis (read real books, challenge yourself by getting out of your intellectual comfort zone). Studies show that coffee is good for Alzheimer's, so as long as you're not using it to stay awake when you need sleep, it's probably fine.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#20

My mother has dementia, and I know 5 other close friends that are starting to deal with it as well. This is becoming an epidemic and what people don’t realize is that it is extremely expensive and exceedingly cruel. Most health care systems, including Canada and the US, do not handle dementia well at all. You have the choice of becoming financially destitute keeping your parents in a dignified setting, or you can let…

My mother was purposely financially destitute when she died post dementia. It was the only way for the state to help pay for services without collecting everything (house, car, pension, etc). Later we were able to put her on hospice and that offered much more assistance.

I cannot describe the stress in trying to figure out financials as a loved one is dying. It led to many sleepless nights...

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