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over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
> One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart. The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70%. All results were statistically significant (pAlso:
> and no hospitalisations or severe cases of the disease were reported in participants receiving the vaccine.
https://www.astrazeneca.com/media-centre/press-releases/2020...
over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
The business-as-usual replication rate of covid appears to be somewhere around 4-6, meaning that if we have universal vaccination with something like 80% efficacy, the number of active cases will exponentially decay with no other measures taken (social distancing, masks, lockdowns, quarantines etc).
From AstraZeneca: > One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart. The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70%. All results were statistically significa…
"These preliminary data indicate that the vaccine is 70.4% effective, with tests on two different dose regimens showing that the vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses."
Does anyone here who understands vaccines know how starting with a smaller does can improve effectiveness? It goes against my intuition.
Is that also true of the Pfizer and Moderna trials? Are the various trials measuring 'effectiveness' in the same way? Is there a standard for 'effectiveness' in these Covid-19 trials?
It will take some digging and real effort to compare the risks and benefits of the various vaccines coming to market.
This is awesome for more than just vaccinations. Traditionally the groups allocating govt funding to science and industries are very risk averse and this could be one more example where taking risks can payoff.
over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
People infected by SARS-Cov2 seem to infect two to six other people [0]. Reduce this number by 90% and we are well below one infection per infected, so it is not sustained. This assumes that everyone would be vaccinated.
Currently we are doing something similar: each measure like wearing a mask, social distancing, meeting fewer people, ventilating rooms, finding infected people before they can infect someone else ("contact tracing") contributes to reducing the number of follow-up infections a bit. (This is why "but masks do not really work" is an ill-informed argument. They do not have to because they are meant to be used together with other measures to achieve reduction in spread)
A vaccine will protect us passively instead of requiring us to actively following these measures and will therefore be a lot more convenient.
over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
Covid is apparently around 3, and if you can vaccinate 90% of the population then an effectiveness of 75% would be the minimum you could get away with.
over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
Keep in mind, that controlling covid is a giant win. We don't need to eradicate it, just get things under control.