Covid-19 had us all fooled, but now we might have finally found its secret • Hacker News Board

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#11

Post by g3e0 » Tue, Apr 07, 2020, 3:48 PM UTC

tomohawk wrote: post #7

A family member is a nurse treating these patients at the hospital. She was relating how the blood of covid patients has a very different color. It is very dark. Is that related to this? EDIT: She also noted that many of the patients were breathing fine, but their pulse ox would just drop and drop. EDIT2: really? downvotes for asking a questions and seeking info?

I am not a doctor, but if true, that sounds completely consistent with this hypothesis (deoxygenated blood is darker, and being able to breathe won't help if your hemoglobin can't carry oxygen)

I would be fascinated to hear their take on this article.

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#12

Post by jstewartmobile » Tue, Apr 07, 2020, 4:10 PM UTC

mtmail wrote: post #5

I'm with "Be aware that the author has low trust factor and may have put the piece together from other sources without having a clue what he was writing about." until I see credentials. http://www.smalldeadanimals.com/index.php/2020/04/05/wuhan-f... "All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as th…

If his methodology is not on point, his hypothesis should be waaaay off point, and very easy to debunk.

If that is the case, why are you attacking his lack of credentials and politics instead of his hypothesis?

edit: here is an actual paper saying the same thing the medium post is

https://chemrxiv.org/ndownloader/files/22129965

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#13

Post by mensetmanusman » Tue, Apr 07, 2020, 6:08 PM UTC

Let’s hope this is accurate! If we have a straightforward way to cope with dropping O2 values in blood, this is great.

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#14

Post by nunez » Tue, Apr 07, 2020, 6:09 PM UTC

Not sure of the OP’s credentials but this has been discussed often in /r/COVID19 and has some truth to it

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#15

Post by spottedmahn » Tue, Apr 07, 2020, 8:14 PM UTC

newsbinator wrote: post #2

I read this the other day (before it got blocked on Medium) and to my layman eyes it sounded plausible. But I'm not a medical researcher and this is not medical research- it's more of a guess. I'm looking forward to some expert comments here on whether this theory has any basis in reality.

>I read this the other day (before it got blocked on Medium)

Do you have a link you can share about medium blocking it? thanks!

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#16

Post by saminaustin » Wed, Apr 08, 2020, 1:06 AM UTC

Based on this paper. There seems to be merit to the argument.

Essentially these researchers claim that they modeled the corona virus surface proteins and found that they will bind to hemoglobin and cause it to release the iron atom - making it non-functional. This leads to the other symptoms of COVID-19. Given the severity of the outbreak it is certainly a hypothesis that others should test to validate or discredit. But based on scientific analysis, not just twitter snarking.

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf...

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#17

Post by cincijones » Wed, Apr 08, 2020, 4:20 AM UTC

This is totally incorrect. First, the MOA of hydroxychloroquinoline (HCQ) in malaria is completely incorrect. It works through lysosomal function regarding the presentation of antigens to the immune system. Secondly, Covid-19 is not a DNA virus but an RNA virus, DNA is not involved nor is an interaction with hemoglobin involved in the anti-malaria activity of HCQ. There is nothing in the scientific/medical lit as of today about any interaction with hemoglobin and covid-19, nor any reason to think HCQ would interfere in such process. (WKJ, Professor of Pharmacology)

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#18

Post by SeekerOfOne » Wed, Apr 08, 2020, 5:09 AM UTC

cincijones wrote: post #17

This is totally incorrect. First, the MOA of hydroxychloroquinoline (HCQ) in malaria is completely incorrect. It works through lysosomal function regarding the presentation of antigens to the immune system. Secondly, Covid-19 is not a DNA virus but an RNA virus, DNA is not involved nor is an interaction with hemoglobin involved in the anti-malaria activity of HCQ. There is nothing in the scientific/medical lit as of…

I believe this paper qualifies as scientific/medical lit:

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism SOURCE: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf...

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#19

Post by TonRoly » Wed, Apr 08, 2020, 9:06 AM UTC

I am not a doctor... I am just a regular person who doesn’t understand why articles and posts similar to this including videos on YouTube, Facebook and other places are being removed.

I found this to be an interesting article and true or false Doesn’t it fall under the Freedom of Speech... I sent this link to several people I know that are in the medical industry one of which is a brilliant doctor on the front lines saving lives at NCH hospital in Naples Florida... but before she sees it it is no longer available...

I track this to this thread and see everyone debating everything from politics to science... yet why was this removed I. The first place? I’m sorry but when my mother raised me she was adamant about the point that we could say anything we wanted to anyone that we wanted and as long as it didn’t hurt anybody we were free to do so… Now I’m finding it very disturbing situation where information that I felt was important and needed to be looked at by people that I needed to trust to tell me if it was correct or not etc. etc. now it’s gone and I come to this group debating… And thank goodness I found out about this.

Re: Covid-19 had us all fooled, but now we might have finally found its secret

#20

Post by TonRoly » Wed, Apr 08, 2020, 9:09 AM UTC

jstewartmobile wrote: post #12

mtmail wrote: post #5

I'm with "Be aware that the author has low trust factor and may have put the piece together from other sources without having a clue what he was writing about." until I see credentials. http://www.smalldeadanimals.com/index.php/2020/04/05/wuhan-f... "All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as th…

If his methodology is not on point, his hypothesis should be waaaay off point, and very easy to debunk. If that is the case, why are you attacking his lack of credentials and politics instead of his hypothesis? edit: here is an actual paper saying the same thing the medium post is https://chemrxiv.org/ndownloader/files/22129965

Thank you for your argument... Seems we are losing our freedom of speech and expression...